Bilirubin Interactions with Different Proteins and Implications of These Interactions
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2022
Book part (Published version)
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Nova Science Publishers, Inc.
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Bilirubin is a tetrapyrrole, yellow pigment, and it is a degradation product
created in heme metabolism. This molecule is predominantly present in
its unconjugated form in circulation, and it is mainly bound to human
serum albumin. The presence of small amounts of free, unconjugated
bilirubin enables its interactions with other circulation components. In
conditions like Gilbert syndrome or diabetes, the concentration of
unconjugated bilirubin increases in the blood, making other interacting
partners from circulation more important for its metabolism. In the liver,
bilirubin is converted to conjugated form, which is then excreted from
the organism. While the significant increase of bilirubin is toxic, research
suggests that small increases may be beneficial since bilirubin has
antioxidative and anticancer potential. In this chapter, interactions of
bilirubin with several proteins will be described together with the effects
of these interactions on the protein’s structure an...d function.
Keywords:
bilirubin / protein binding / metabolism / phycocyanobilinSource:
Advances in Biology, 2022, 1, 85-122Publisher:
- New York: Nova Science Publishers, Inc.
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200168 (University of Belgrade, Faculty of Chemistry) (RS-MESTD-inst-2020-200168)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200019 (University of Belgrade, Institute for the Application of Nuclear Energy - INEP) (RS-MESTD-inst-2020-200019)
Note:
- Category M14 /Kategorija M14
Institution/Community
IHTMTY - CHAP AU - Gligorijević, Nikola AU - Minić, Simeon PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6486 AB - Bilirubin is a tetrapyrrole, yellow pigment, and it is a degradation product created in heme metabolism. This molecule is predominantly present in its unconjugated form in circulation, and it is mainly bound to human serum albumin. The presence of small amounts of free, unconjugated bilirubin enables its interactions with other circulation components. In conditions like Gilbert syndrome or diabetes, the concentration of unconjugated bilirubin increases in the blood, making other interacting partners from circulation more important for its metabolism. In the liver, bilirubin is converted to conjugated form, which is then excreted from the organism. While the significant increase of bilirubin is toxic, research suggests that small increases may be beneficial since bilirubin has antioxidative and anticancer potential. In this chapter, interactions of bilirubin with several proteins will be described together with the effects of these interactions on the protein’s structure and function. PB - New York: Nova Science Publishers, Inc. T2 - Advances in Biology T1 - Bilirubin Interactions with Different Proteins and Implications of These Interactions VL - 1 SP - 85 EP - 122 UR - https://hdl.handle.net/21.15107/rcub_cer_6486 ER -
@inbook{ author = "Gligorijević, Nikola and Minić, Simeon", year = "2022", abstract = "Bilirubin is a tetrapyrrole, yellow pigment, and it is a degradation product created in heme metabolism. This molecule is predominantly present in its unconjugated form in circulation, and it is mainly bound to human serum albumin. The presence of small amounts of free, unconjugated bilirubin enables its interactions with other circulation components. In conditions like Gilbert syndrome or diabetes, the concentration of unconjugated bilirubin increases in the blood, making other interacting partners from circulation more important for its metabolism. In the liver, bilirubin is converted to conjugated form, which is then excreted from the organism. While the significant increase of bilirubin is toxic, research suggests that small increases may be beneficial since bilirubin has antioxidative and anticancer potential. In this chapter, interactions of bilirubin with several proteins will be described together with the effects of these interactions on the protein’s structure and function.", publisher = "New York: Nova Science Publishers, Inc.", journal = "Advances in Biology", booktitle = "Bilirubin Interactions with Different Proteins and Implications of These Interactions", volume = "1", pages = "85-122", url = "https://hdl.handle.net/21.15107/rcub_cer_6486" }
Gligorijević, N.,& Minić, S.. (2022). Bilirubin Interactions with Different Proteins and Implications of These Interactions. in Advances in Biology New York: Nova Science Publishers, Inc.., 1, 85-122. https://hdl.handle.net/21.15107/rcub_cer_6486
Gligorijević N, Minić S. Bilirubin Interactions with Different Proteins and Implications of These Interactions. in Advances in Biology. 2022;1:85-122. https://hdl.handle.net/21.15107/rcub_cer_6486 .
Gligorijević, Nikola, Minić, Simeon, "Bilirubin Interactions with Different Proteins and Implications of These Interactions" in Advances in Biology, 1 (2022):85-122, https://hdl.handle.net/21.15107/rcub_cer_6486 .