Electrochemical determination of duloxetine hydrochloride at gold electrode
Authors
Lović, JelenaMijin, Dušan
Bogdanović, Aleksandra
Vuković, Dragan
Petrović, Slobodan
Avramov - Ivić, Milka
Conference object (Published version)
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Show full item recordAbstract
Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the
uptake of serotonin and norepinephrine. The electrochemical behavior of D U L
was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold
electrode by varying pH and scan rate. The electroanalytical application was
studied with the aid of differential pulse voltammetry (DPV) in sodium
bicarbonate solution. A linear response ranged from 5x10'^ M to 10'" M. The
validation of the DPV method was carried out by determine of the limit of
detection (LOD) and limit of quantitation (LOQ) and the calculate values were
4.6 X 10"'' and 2 x 10'^' M, respective!). The proposed DPV method has been
successfully applied to assessment DUL as standard and in Taita® tablets and
standard spiked with human serum.
Keywords:
Duloxetine hydrochloride / Differential pulse voltammetry / Human serum analysisSource:
Bulletin of the Chemists and Technologists of Bosnia and Herzegovina, 2022, 42-42Publisher:
- Sarajevo : Faculty of Science University of Sarajevo
Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-MESTD-inst-2020-200026)
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Institution/Community
IHTMTY - CONF AU - Lović, Jelena AU - Mijin, Dušan AU - Bogdanović, Aleksandra AU - Vuković, Dragan AU - Petrović, Slobodan AU - Avramov - Ivić, Milka PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6186 AB - Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the uptake of serotonin and norepinephrine. The electrochemical behavior of D U L was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold electrode by varying pH and scan rate. The electroanalytical application was studied with the aid of differential pulse voltammetry (DPV) in sodium bicarbonate solution. A linear response ranged from 5x10'^ M to 10'" M. The validation of the DPV method was carried out by determine of the limit of detection (LOD) and limit of quantitation (LOQ) and the calculate values were 4.6 X 10"'' and 2 x 10'^' M, respective!). The proposed DPV method has been successfully applied to assessment DUL as standard and in Taita® tablets and standard spiked with human serum. PB - Sarajevo : Faculty of Science University of Sarajevo C3 - Bulletin of the Chemists and Technologists of Bosnia and Herzegovina T1 - Electrochemical determination of duloxetine hydrochloride at gold electrode SP - 42 EP - 42 UR - https://hdl.handle.net/21.15107/rcub_cer_6186 ER -
@conference{ author = "Lović, Jelena and Mijin, Dušan and Bogdanović, Aleksandra and Vuković, Dragan and Petrović, Slobodan and Avramov - Ivić, Milka", year = "2022", abstract = "Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the uptake of serotonin and norepinephrine. The electrochemical behavior of D U L was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold electrode by varying pH and scan rate. The electroanalytical application was studied with the aid of differential pulse voltammetry (DPV) in sodium bicarbonate solution. A linear response ranged from 5x10'^ M to 10'" M. The validation of the DPV method was carried out by determine of the limit of detection (LOD) and limit of quantitation (LOQ) and the calculate values were 4.6 X 10"'' and 2 x 10'^' M, respective!). The proposed DPV method has been successfully applied to assessment DUL as standard and in Taita® tablets and standard spiked with human serum.", publisher = "Sarajevo : Faculty of Science University of Sarajevo", journal = "Bulletin of the Chemists and Technologists of Bosnia and Herzegovina", title = "Electrochemical determination of duloxetine hydrochloride at gold electrode", pages = "42-42", url = "https://hdl.handle.net/21.15107/rcub_cer_6186" }
Lović, J., Mijin, D., Bogdanović, A., Vuković, D., Petrović, S.,& Avramov - Ivić, M.. (2022). Electrochemical determination of duloxetine hydrochloride at gold electrode. in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina Sarajevo : Faculty of Science University of Sarajevo., 42-42. https://hdl.handle.net/21.15107/rcub_cer_6186
Lović J, Mijin D, Bogdanović A, Vuković D, Petrović S, Avramov - Ivić M. Electrochemical determination of duloxetine hydrochloride at gold electrode. in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina. 2022;:42-42. https://hdl.handle.net/21.15107/rcub_cer_6186 .
Lović, Jelena, Mijin, Dušan, Bogdanović, Aleksandra, Vuković, Dragan, Petrović, Slobodan, Avramov - Ivić, Milka, "Electrochemical determination of duloxetine hydrochloride at gold electrode" in Bulletin of the Chemists and Technologists of Bosnia and Herzegovina (2022):42-42, https://hdl.handle.net/21.15107/rcub_cer_6186 .