Omicron BA.2.75 Sublineage (Centaurus) Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate. Omicron BA.2.75 is a subvariant believed to be able to suppress the currently dominant BA.5 and cause a new winter wave of the COVID-19 pandemic. Omicron BA.2.75 is characterized by a greater infectivity compared to earlier Omicron variants. However, the Gibbs energy of the biosynthesis of virus particles is slightly less negative compared to those of other variants. Thus, the multiplication rate of Omicron BA.2.75 is lower than that of other SARS-CoV-2 variants. This leads to slower accumulation of newly formed virions and less damage to host cells, indicating evolution of SARS-CoV-2 toward decreasing pathogenicity.
Кључне речи:
COVID-19 / SARS-CoV-2 / pandemic / empirical formula / growth stoichiometry / thermodynamic properties / multiplication rate; enthalpy; entropy; biothermodynamics / enthalpy / entropy / biothermodynamicsИзвор:
Microbiology Research, 2022, 13, 4, 937-952Издавач:
- MDPI
Институција/група
IHTMTY - JOUR AU - Popović, Marko PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6109 AB - SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate. Omicron BA.2.75 is a subvariant believed to be able to suppress the currently dominant BA.5 and cause a new winter wave of the COVID-19 pandemic. Omicron BA.2.75 is characterized by a greater infectivity compared to earlier Omicron variants. However, the Gibbs energy of the biosynthesis of virus particles is slightly less negative compared to those of other variants. Thus, the multiplication rate of Omicron BA.2.75 is lower than that of other SARS-CoV-2 variants. This leads to slower accumulation of newly formed virions and less damage to host cells, indicating evolution of SARS-CoV-2 toward decreasing pathogenicity. PB - MDPI T2 - Microbiology Research T1 - Omicron BA.2.75 Sublineage (Centaurus) Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity VL - 13 IS - 4 SP - 937 EP - 952 DO - 10.3390/microbiolres13040066 ER -
@article{ author = "Popović, Marko", year = "2022", abstract = "SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate. Omicron BA.2.75 is a subvariant believed to be able to suppress the currently dominant BA.5 and cause a new winter wave of the COVID-19 pandemic. Omicron BA.2.75 is characterized by a greater infectivity compared to earlier Omicron variants. However, the Gibbs energy of the biosynthesis of virus particles is slightly less negative compared to those of other variants. Thus, the multiplication rate of Omicron BA.2.75 is lower than that of other SARS-CoV-2 variants. This leads to slower accumulation of newly formed virions and less damage to host cells, indicating evolution of SARS-CoV-2 toward decreasing pathogenicity.", publisher = "MDPI", journal = "Microbiology Research", title = "Omicron BA.2.75 Sublineage (Centaurus) Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity", volume = "13", number = "4", pages = "937-952", doi = "10.3390/microbiolres13040066" }
Popović, M.. (2022). Omicron BA.2.75 Sublineage (Centaurus) Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity. in Microbiology Research MDPI., 13(4), 937-952. https://doi.org/10.3390/microbiolres13040066
Popović M. Omicron BA.2.75 Sublineage (Centaurus) Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity. in Microbiology Research. 2022;13(4):937-952. doi:10.3390/microbiolres13040066 .
Popović, Marko, "Omicron BA.2.75 Sublineage (Centaurus) Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity" in Microbiology Research, 13, no. 4 (2022):937-952, https://doi.org/10.3390/microbiolres13040066 . .