Strain wars 5: Gibbs energies of binding of BA.1 through BA.4 variants of SARS-CoV-2
Само за регистроване кориснике
2022
Чланак у часопису (Објављена верзија)
,
Elsevier
Метаподаци
Приказ свих података о документуАпстракт
This paper reports, for the first time, standard Gibbs energies of binding of the BA.1, BA.2, BA.3, BA.2.13, BA.2.12.1 and BA.4 Omicron variants of SARS-CoV-2, to the Human ACE2 receptor. Variants BA.1 through BA.3 exhibit a trend of decreasing standard Gibbs energy of binding and hence increased infectivity. The BA.4 variant exhibits a less negative standard Gibbs energy of binding, but also more efficient evasion of the immune response. Therefore, it was concluded that all the analyzed strains evolve in accordance with expectations of the theory of evolution, albeit using different strategies.
Кључне речи:
Antigen-receptor binding / Binding constant / Dissociation constant / Evolution / Omicron variantИзвор:
Microbial Risk Analysis, 2022, 22, 100231-Издавач:
- Elsevier
DOI: 10.1016/j.mran.2022.100231
ISSN: 2352-3522
PubMed: 36034590
Scopus: 2-s2.0-85136688176
Институција/група
IHTMTY - JOUR AU - Popović, Marko PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6054 AB - This paper reports, for the first time, standard Gibbs energies of binding of the BA.1, BA.2, BA.3, BA.2.13, BA.2.12.1 and BA.4 Omicron variants of SARS-CoV-2, to the Human ACE2 receptor. Variants BA.1 through BA.3 exhibit a trend of decreasing standard Gibbs energy of binding and hence increased infectivity. The BA.4 variant exhibits a less negative standard Gibbs energy of binding, but also more efficient evasion of the immune response. Therefore, it was concluded that all the analyzed strains evolve in accordance with expectations of the theory of evolution, albeit using different strategies. PB - Elsevier T2 - Microbial Risk Analysis T1 - Strain wars 5: Gibbs energies of binding of BA.1 through BA.4 variants of SARS-CoV-2 VL - 22 SP - 100231 DO - 10.1016/j.mran.2022.100231 ER -
@article{ author = "Popović, Marko", year = "2022", abstract = "This paper reports, for the first time, standard Gibbs energies of binding of the BA.1, BA.2, BA.3, BA.2.13, BA.2.12.1 and BA.4 Omicron variants of SARS-CoV-2, to the Human ACE2 receptor. Variants BA.1 through BA.3 exhibit a trend of decreasing standard Gibbs energy of binding and hence increased infectivity. The BA.4 variant exhibits a less negative standard Gibbs energy of binding, but also more efficient evasion of the immune response. Therefore, it was concluded that all the analyzed strains evolve in accordance with expectations of the theory of evolution, albeit using different strategies.", publisher = "Elsevier", journal = "Microbial Risk Analysis", title = "Strain wars 5: Gibbs energies of binding of BA.1 through BA.4 variants of SARS-CoV-2", volume = "22", pages = "100231", doi = "10.1016/j.mran.2022.100231" }
Popović, M.. (2022). Strain wars 5: Gibbs energies of binding of BA.1 through BA.4 variants of SARS-CoV-2. in Microbial Risk Analysis Elsevier., 22, 100231. https://doi.org/10.1016/j.mran.2022.100231
Popović M. Strain wars 5: Gibbs energies of binding of BA.1 through BA.4 variants of SARS-CoV-2. in Microbial Risk Analysis. 2022;22:100231. doi:10.1016/j.mran.2022.100231 .
Popović, Marko, "Strain wars 5: Gibbs energies of binding of BA.1 through BA.4 variants of SARS-CoV-2" in Microbial Risk Analysis, 22 (2022):100231, https://doi.org/10.1016/j.mran.2022.100231 . .