Sinteza, karakterizacija i antimikrobna aktivnost kompleksa Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline

Abstract

Kompleks Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline (H2L) je dobijen direktnom sintezom. Prekristalizacijom je dobijen monokristalni proizvod te je struktura kompleksa rešena primenom rendgenske strukturne analize. U unutrašnjoj sferi binuklearnog simetrinog kompleksa, sa distorgovanom oktaedarskom geometrijom oko jona Cu(II), jedan molekul liganda je koordinovan u anjonskom, a drugi u neutralnom obliku, oba bis-tridentatno preko N,N,O seta donorskih atoma. U spoljašnjoj sferi kompleksa se nalaze perhloratni joni i molekuli vode. Kompleks je pokazao antimikrobnu aktivnost u niskom mikromolarnom opsegu na svim testiranim mikroorganizmima.

The Cu(II) complex with the ligand H2L, which is a condensation derivative of 2-acetylpyridine and malonic acid dihydrazide, was obtained by direct synthesis. Recrystallization gave a single crystal product, and the structure of the complex was solved by X-ray structural analysis. In the inner sphere of the binuclear symmetrical complex, with distorted octahedral geometry around Cu(II) ions, one ligand molecule is coordinated in anionic and the other in neutral form, both bis-tridentaly via the N, N, O set of donor atoms. Perchlorate ions and water molecules are located in the outer sphere of the complex. The complex showed antimicrobial activity in the low micromolar range on all tested microorganisms.