Sinteza, karakterizacija i antimikrobna aktivnost kompleksa Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline
Synthesis, characterization and antimicrobial activity of Cu(II) complex with condensation derivative of 2-acetylpyridine and malonic acid dihydrazide
Abstract
Kompleks Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline (H2L) je dobijen direktnom sintezom. Prekristalizacijom je dobijen monokristalni proizvod te je struktura kompleksa rešena primenom rendgenske strukturne analize. U unutrašnjoj sferi binuklearnog simetrinog kompleksa, sa distorgovanom oktaedarskom geometrijom oko jona Cu(II), jedan molekul liganda je koordinovan u anjonskom, a drugi u neutralnom obliku, oba bis-tridentatno preko N,N,O seta donorskih atoma. U spoljašnjoj sferi kompleksa se nalaze perhloratni joni i molekuli vode. Kompleks je pokazao antimikrobnu aktivnost u niskom mikromolarnom opsegu na svim testiranim mikroorganizmima.
The Cu(II) complex with the ligand H2L, which is a condensation derivative of 2-acetylpyridine and malonic acid dihydrazide, was obtained by direct synthesis. Recrystallization gave a single crystal product, and the structure of the complex was solved by X-ray structural analysis. In the inner sphere of the binuclear symmetrical complex, with distorted octahedral geometry around Cu(II) ions, one ligand molecule is coordinated in anionic and the other in neutral form, both bis-tridentaly via the N, N, O set of donor atoms. Perchlorate ions and water molecules are located in the outer sphere of the complex. The complex showed antimicrobial activity in the low micromolar range on all tested microorganisms.
Keywords:
Cu(II) complex / Single crystal / antimicrobial activitySource:
Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine, 2022, 120-120Publisher:
- Belgrade: Serbian Chemical Society
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Institution/Community
IHTMTY - CONF AU - Pavlović, Pavle AU - Rodić, Marko AU - Novaković, Irena AU - Filipović, Nenad AU - Todorović, Tamara PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5784 AB - Kompleks Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline (H2L) je dobijen direktnom sintezom. Prekristalizacijom je dobijen monokristalni proizvod te je struktura kompleksa rešena primenom rendgenske strukturne analize. U unutrašnjoj sferi binuklearnog simetrinog kompleksa, sa distorgovanom oktaedarskom geometrijom oko jona Cu(II), jedan molekul liganda je koordinovan u anjonskom, a drugi u neutralnom obliku, oba bis-tridentatno preko N,N,O seta donorskih atoma. U spoljašnjoj sferi kompleksa se nalaze perhloratni joni i molekuli vode. Kompleks je pokazao antimikrobnu aktivnost u niskom mikromolarnom opsegu na svim testiranim mikroorganizmima. AB - The Cu(II) complex with the ligand H2L, which is a condensation derivative of 2-acetylpyridine and malonic acid dihydrazide, was obtained by direct synthesis. Recrystallization gave a single crystal product, and the structure of the complex was solved by X-ray structural analysis. In the inner sphere of the binuclear symmetrical complex, with distorted octahedral geometry around Cu(II) ions, one ligand molecule is coordinated in anionic and the other in neutral form, both bis-tridentaly via the N, N, O set of donor atoms. Perchlorate ions and water molecules are located in the outer sphere of the complex. The complex showed antimicrobial activity in the low micromolar range on all tested microorganisms. PB - Belgrade: Serbian Chemical Society C3 - Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine T1 - Sinteza, karakterizacija i antimikrobna aktivnost kompleksa Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline T1 - Synthesis, characterization and antimicrobial activity of Cu(II) complex with condensation derivative of 2-acetylpyridine and malonic acid dihydrazide SP - 120 EP - 120 UR - https://hdl.handle.net/21.15107/rcub_cer_5784 ER -
@conference{ author = "Pavlović, Pavle and Rodić, Marko and Novaković, Irena and Filipović, Nenad and Todorović, Tamara", year = "2022", abstract = "Kompleks Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline (H2L) je dobijen direktnom sintezom. Prekristalizacijom je dobijen monokristalni proizvod te je struktura kompleksa rešena primenom rendgenske strukturne analize. U unutrašnjoj sferi binuklearnog simetrinog kompleksa, sa distorgovanom oktaedarskom geometrijom oko jona Cu(II), jedan molekul liganda je koordinovan u anjonskom, a drugi u neutralnom obliku, oba bis-tridentatno preko N,N,O seta donorskih atoma. U spoljašnjoj sferi kompleksa se nalaze perhloratni joni i molekuli vode. Kompleks je pokazao antimikrobnu aktivnost u niskom mikromolarnom opsegu na svim testiranim mikroorganizmima., The Cu(II) complex with the ligand H2L, which is a condensation derivative of 2-acetylpyridine and malonic acid dihydrazide, was obtained by direct synthesis. Recrystallization gave a single crystal product, and the structure of the complex was solved by X-ray structural analysis. In the inner sphere of the binuclear symmetrical complex, with distorted octahedral geometry around Cu(II) ions, one ligand molecule is coordinated in anionic and the other in neutral form, both bis-tridentaly via the N, N, O set of donor atoms. Perchlorate ions and water molecules are located in the outer sphere of the complex. The complex showed antimicrobial activity in the low micromolar range on all tested microorganisms.", publisher = "Belgrade: Serbian Chemical Society", journal = "Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine", title = "Sinteza, karakterizacija i antimikrobna aktivnost kompleksa Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline, Synthesis, characterization and antimicrobial activity of Cu(II) complex with condensation derivative of 2-acetylpyridine and malonic acid dihydrazide", pages = "120-120", url = "https://hdl.handle.net/21.15107/rcub_cer_5784" }
Pavlović, P., Rodić, M., Novaković, I., Filipović, N.,& Todorović, T.. (2022). Sinteza, karakterizacija i antimikrobna aktivnost kompleksa Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline. in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine Belgrade: Serbian Chemical Society., 120-120. https://hdl.handle.net/21.15107/rcub_cer_5784
Pavlović P, Rodić M, Novaković I, Filipović N, Todorović T. Sinteza, karakterizacija i antimikrobna aktivnost kompleksa Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline. in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine. 2022;:120-120. https://hdl.handle.net/21.15107/rcub_cer_5784 .
Pavlović, Pavle, Rodić, Marko, Novaković, Irena, Filipović, Nenad, Todorović, Tamara, "Sinteza, karakterizacija i antimikrobna aktivnost kompleksa Cu(II) sa kondenzacionim derivatom 2-acetilpiridina i dihidrazida malonske kiseline" in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine (2022):120-120, https://hdl.handle.net/21.15107/rcub_cer_5784 .