Sinteza i ispitivanje biološke aktivnosti ariltio i aralkiltio derivata 2-terc-butil-1,4-benzohinona
Synthesis and investigation of biological activity of arylthio and aralkylthio derivatives of 2-tert-butyl-1.4-benzoquinone
Abstract
Sintetisana su dva ariltio i dva aralkiltio derivata 2-terc-butil-1,4-benzohinona reakcijom Michael-ove adicije tiola na hinonsko jezgro u etanolu. Dobijenim derivatima je ispitana antimikrobna i antioksidativna aktivnost, kao i toksinost na raie Artemia salina. Najjau antimikrobnu aktivnost je pokazao derivat 4, najveu antioksidativnu aktivnost je imao derivat 2 (IC50=0,0526 mM), dok je toksinost prema raiima ispoljio samo derivat 4 (LC50=0,032 mM).
Two arylthio and aralkylthio derivatives of 2-tert-butyl-1.4-benzoquinone were synthesized by Michael addition of thiols on quionone moiety in ethanol. For all compounds antimicrobial and antioxidant activity was investigated, as well as toxicity towards nauplii of Artemia salina. Derivative 4 showed the strongest antimicrobial activity, derivative 2 showed the most intense antioxidant activity (IC50=0.0526 mM), while only derivative 4 showed toxicity against nauplii of A. salina (LC50=0.032 mM).
Keywords:
Michael addition / thiols / quionone / antimicrobial activity / antioxidant activitySource:
Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine, 2022, 90-90Publisher:
- Belgrade: Serbian Chemical Society
Collections
Institution/Community
IHTMTY - CONF AU - Kovačević, Andrej AU - Novaković, Irena AU - Sladić, Dušan PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5782 AB - Sintetisana su dva ariltio i dva aralkiltio derivata 2-terc-butil-1,4-benzohinona reakcijom Michael-ove adicije tiola na hinonsko jezgro u etanolu. Dobijenim derivatima je ispitana antimikrobna i antioksidativna aktivnost, kao i toksinost na raie Artemia salina. Najjau antimikrobnu aktivnost je pokazao derivat 4, najveu antioksidativnu aktivnost je imao derivat 2 (IC50=0,0526 mM), dok je toksinost prema raiima ispoljio samo derivat 4 (LC50=0,032 mM). AB - Two arylthio and aralkylthio derivatives of 2-tert-butyl-1.4-benzoquinone were synthesized by Michael addition of thiols on quionone moiety in ethanol. For all compounds antimicrobial and antioxidant activity was investigated, as well as toxicity towards nauplii of Artemia salina. Derivative 4 showed the strongest antimicrobial activity, derivative 2 showed the most intense antioxidant activity (IC50=0.0526 mM), while only derivative 4 showed toxicity against nauplii of A. salina (LC50=0.032 mM). PB - Belgrade: Serbian Chemical Society C3 - Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine T1 - Sinteza i ispitivanje biološke aktivnosti ariltio i aralkiltio derivata 2-terc-butil-1,4-benzohinona T1 - Synthesis and investigation of biological activity of arylthio and aralkylthio derivatives of 2-tert-butyl-1.4-benzoquinone SP - 90 EP - 90 UR - https://hdl.handle.net/21.15107/rcub_cer_5782 ER -
@conference{ author = "Kovačević, Andrej and Novaković, Irena and Sladić, Dušan", year = "2022", abstract = "Sintetisana su dva ariltio i dva aralkiltio derivata 2-terc-butil-1,4-benzohinona reakcijom Michael-ove adicije tiola na hinonsko jezgro u etanolu. Dobijenim derivatima je ispitana antimikrobna i antioksidativna aktivnost, kao i toksinost na raie Artemia salina. Najjau antimikrobnu aktivnost je pokazao derivat 4, najveu antioksidativnu aktivnost je imao derivat 2 (IC50=0,0526 mM), dok je toksinost prema raiima ispoljio samo derivat 4 (LC50=0,032 mM)., Two arylthio and aralkylthio derivatives of 2-tert-butyl-1.4-benzoquinone were synthesized by Michael addition of thiols on quionone moiety in ethanol. For all compounds antimicrobial and antioxidant activity was investigated, as well as toxicity towards nauplii of Artemia salina. Derivative 4 showed the strongest antimicrobial activity, derivative 2 showed the most intense antioxidant activity (IC50=0.0526 mM), while only derivative 4 showed toxicity against nauplii of A. salina (LC50=0.032 mM).", publisher = "Belgrade: Serbian Chemical Society", journal = "Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine", title = "Sinteza i ispitivanje biološke aktivnosti ariltio i aralkiltio derivata 2-terc-butil-1,4-benzohinona, Synthesis and investigation of biological activity of arylthio and aralkylthio derivatives of 2-tert-butyl-1.4-benzoquinone", pages = "90-90", url = "https://hdl.handle.net/21.15107/rcub_cer_5782" }
Kovačević, A., Novaković, I.,& Sladić, D.. (2022). Sinteza i ispitivanje biološke aktivnosti ariltio i aralkiltio derivata 2-terc-butil-1,4-benzohinona. in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine Belgrade: Serbian Chemical Society., 90-90. https://hdl.handle.net/21.15107/rcub_cer_5782
Kovačević A, Novaković I, Sladić D. Sinteza i ispitivanje biološke aktivnosti ariltio i aralkiltio derivata 2-terc-butil-1,4-benzohinona. in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine. 2022;:90-90. https://hdl.handle.net/21.15107/rcub_cer_5782 .
Kovačević, Andrej, Novaković, Irena, Sladić, Dušan, "Sinteza i ispitivanje biološke aktivnosti ariltio i aralkiltio derivata 2-terc-butil-1,4-benzohinona" in Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, Belgrade, Serbia, June 9-10, 2022 / Kratki izvodi radova, kjniga radova - 58. Savetovanje Srpskog hemijskog društva, Beograd 9. i 10. jun 2022. godine (2022):90-90, https://hdl.handle.net/21.15107/rcub_cer_5782 .