Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation
Аутори
Baralić, MarkoPažitná, Lucia
Brković, Voin
Laušević, Mirjana
Gligorijević, Nikola
Katrlík, Jaroslav
Nedić, Olgica
Robajac, Dragana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
As we already reported, fibrinogen fucosylation emerged as a prognostic marker of peritoneal
membrane function in end-stage renal disease (ESRD) patients on peritoneal dialysis. After a
follow-up period of 18 months, we estimated the ability of employed lectins, as well as other biochemical
parameters, to serve as mortality predictors in these patients. Following a univariate Cox
regression analysis, ferritin, urea clearance, residual diuresis, hyperglycemia, and an increase in the
signal intensity obtained with Galanthus nivalis lectin (GNL) emerged as potential mortality predictors,
but additional multivariate Cox regression analysis pointed only to glucose concentration
and GNL as mortality predictors. Higher signal intensity obtained with GNL in patients that died
suggested the importance of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen
as factors that are related to unwanted cardiovascular events and all-cause mortality and can possibly
be seen as a... prediction tool. Altered glycan structures composed of mannose residues are expected
to affect the reactivity of mannosylated glycoproteins with mannose-binding lectin and possibly
the entire cascade of events linked to this lectin. Since patients with ESRD are prone to cardiovascular
complications and the formation of atherosclerotic plaques, one can hypothesize that fibrinogen
with increasingly exposed mannose residues may contribute to the unwanted events.
Кључне речи:
ESRD / CKD / glycosylation / N-glycansИзвор:
Cells, 2023, 12, 351Издавач:
- Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200019 (Универзитет у Београду, Институт за примену нуклеарне енергије - ИНЕП) (RS-MESTD-inst-2020-200019)
- The Bilateral Cooperation project with the Republic of Slovakia (Grant no. 337-00-107/2019-09/12)
- Grant APVV SK-SRB-21- 0046
- Grant VEGA 2/0120/22
- Grant APVV-20-0243
- The European Regional Development Fund ( the project implementation CEMBAM–Centre for Medical Bio-Additive Manufacturing and Research, ITMS2014+: 313011V358)
DOI: 10.3390/cells12030351
ISSN: 2073-4409
PubMed: 36766693
WoS: 000933785400001
Scopus: 2-s2.0-85147891487
Институција/група
IHTMTY - JOUR AU - Baralić, Marko AU - Pažitná, Lucia AU - Brković, Voin AU - Laušević, Mirjana AU - Gligorijević, Nikola AU - Katrlík, Jaroslav AU - Nedić, Olgica AU - Robajac, Dragana PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5664 AB - As we already reported, fibrinogen fucosylation emerged as a prognostic marker of peritoneal membrane function in end-stage renal disease (ESRD) patients on peritoneal dialysis. After a follow-up period of 18 months, we estimated the ability of employed lectins, as well as other biochemical parameters, to serve as mortality predictors in these patients. Following a univariate Cox regression analysis, ferritin, urea clearance, residual diuresis, hyperglycemia, and an increase in the signal intensity obtained with Galanthus nivalis lectin (GNL) emerged as potential mortality predictors, but additional multivariate Cox regression analysis pointed only to glucose concentration and GNL as mortality predictors. Higher signal intensity obtained with GNL in patients that died suggested the importance of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen as factors that are related to unwanted cardiovascular events and all-cause mortality and can possibly be seen as a prediction tool. Altered glycan structures composed of mannose residues are expected to affect the reactivity of mannosylated glycoproteins with mannose-binding lectin and possibly the entire cascade of events linked to this lectin. Since patients with ESRD are prone to cardiovascular complications and the formation of atherosclerotic plaques, one can hypothesize that fibrinogen with increasingly exposed mannose residues may contribute to the unwanted events. PB - Switzerland : Multidisciplinary Digital Publishing Institute (MDPI) T2 - Cells T1 - Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation VL - 12 IS - 351 DO - 10.3390/cells12030351 ER -
@article{ author = "Baralić, Marko and Pažitná, Lucia and Brković, Voin and Laušević, Mirjana and Gligorijević, Nikola and Katrlík, Jaroslav and Nedić, Olgica and Robajac, Dragana", year = "2023", abstract = "As we already reported, fibrinogen fucosylation emerged as a prognostic marker of peritoneal membrane function in end-stage renal disease (ESRD) patients on peritoneal dialysis. After a follow-up period of 18 months, we estimated the ability of employed lectins, as well as other biochemical parameters, to serve as mortality predictors in these patients. Following a univariate Cox regression analysis, ferritin, urea clearance, residual diuresis, hyperglycemia, and an increase in the signal intensity obtained with Galanthus nivalis lectin (GNL) emerged as potential mortality predictors, but additional multivariate Cox regression analysis pointed only to glucose concentration and GNL as mortality predictors. Higher signal intensity obtained with GNL in patients that died suggested the importance of paucimannosidic/highly mannosidic N-glycan structures on fibrinogen as factors that are related to unwanted cardiovascular events and all-cause mortality and can possibly be seen as a prediction tool. Altered glycan structures composed of mannose residues are expected to affect the reactivity of mannosylated glycoproteins with mannose-binding lectin and possibly the entire cascade of events linked to this lectin. Since patients with ESRD are prone to cardiovascular complications and the formation of atherosclerotic plaques, one can hypothesize that fibrinogen with increasingly exposed mannose residues may contribute to the unwanted events.", publisher = "Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)", journal = "Cells", title = "Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation", volume = "12", number = "351", doi = "10.3390/cells12030351" }
Baralić, M., Pažitná, L., Brković, V., Laušević, M., Gligorijević, N., Katrlík, J., Nedić, O.,& Robajac, D.. (2023). Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation. in Cells Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)., 12(351). https://doi.org/10.3390/cells12030351
Baralić M, Pažitná L, Brković V, Laušević M, Gligorijević N, Katrlík J, Nedić O, Robajac D. Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation. in Cells. 2023;12(351). doi:10.3390/cells12030351 .
Baralić, Marko, Pažitná, Lucia, Brković, Voin, Laušević, Mirjana, Gligorijević, Nikola, Katrlík, Jaroslav, Nedić, Olgica, Robajac, Dragana, "Prediction of Mortality in Patients on Peritoneal Dialysis Based on the Fibrinogen Mannosylation" in Cells, 12, no. 351 (2023), https://doi.org/10.3390/cells12030351 . .