Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites
Само за регистроване кориснике
2022
Аутори
Pergal, MarijaDojčinović, Biljana
Nikodinović-Runić, Jasmina
Dražić, Goran
Zabukovec Logar, Nataša
Ostojić, Sanja
Antić, Bratislav
Чланак у часопису (Објављена верзија)
,
The Authors
Метаподаци
Приказ свих података о документуАпстракт
In situ polymerization was used to produce novel AgFeO2@PEG/polyurethane network nanocomposites (NP-PUs) with 30–60 wt% of soft poly(dimethylsiloxane) segments in polyurethane (PU), containing 1 wt% of PEG-coated AgFeO2 nanoparticles, AgFeO2@PEG. Physicochemical properties and in vitro biological activity of the NP-PUs were systematically evaluated in terms of AgFeO2@PEG (NP) addition and soft segment content. High-angle annular dark-field transmission electron microscopy showed that the nanoparticles were generally uniformly distributed in the PU matrix. Increased soft segment content caused significantly increased intensity of the broad, amorphous X-ray diffraction peaks of crystalline AgFeO2, probably because the chemical composition of PU affected the distribution of nanoparticles. The Young modulus, hardness, and plasticity of the NP-PUs were higher than for pure PU and increased with decreasing soft segment content. Decreased soft segment content induced higher microphase separat...ion, increased hydrophilicity and swelling ability, but decreased cross-linking density. Additionally, NP-PUs had higher glass transition temperatures, improved thermal stability, and enhanced nanomechanical performance over pure PU. The NP-PUs demonstrated good selective inhibition of Candida albicans and Candida parapsilosis (30–55%) and no pronounced cytotoxicity to MRC5 human lung fibroblasts. Among the investigated AgFeO2@PEG/PUs, the best antifungal activity was shown by composites with 30 and 40 wt% soft segments. Consequently, the novel AgFeO2@PEG/polyurethane network nanocomposites could be further optimized to be used as biocompatible surfaces that also prevent formation of fungal biofilms.
Кључне речи:
polymerization / nanocomposites / antifungal activity / AgFeO2@PEG/polyurethaneИзвор:
Journal of Materials Science, 2022, 57, 16, 7827-7848Издавач:
- Springer
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Slovenian Research Agency (P2-0393)
- Slovenian Research Agency (P1-0021)
DOI: 10.1007/s10853-022-07178-9
ISSN: 0022-2461; 1573-4803
WoS: 00078404370001
Scopus: 2-s2.0-85128298290
Институција/група
IHTMTY - JOUR AU - Pergal, Marija AU - Dojčinović, Biljana AU - Nikodinović-Runić, Jasmina AU - Dražić, Goran AU - Zabukovec Logar, Nataša AU - Ostojić, Sanja AU - Antić, Bratislav PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5586 AB - In situ polymerization was used to produce novel AgFeO2@PEG/polyurethane network nanocomposites (NP-PUs) with 30–60 wt% of soft poly(dimethylsiloxane) segments in polyurethane (PU), containing 1 wt% of PEG-coated AgFeO2 nanoparticles, AgFeO2@PEG. Physicochemical properties and in vitro biological activity of the NP-PUs were systematically evaluated in terms of AgFeO2@PEG (NP) addition and soft segment content. High-angle annular dark-field transmission electron microscopy showed that the nanoparticles were generally uniformly distributed in the PU matrix. Increased soft segment content caused significantly increased intensity of the broad, amorphous X-ray diffraction peaks of crystalline AgFeO2, probably because the chemical composition of PU affected the distribution of nanoparticles. The Young modulus, hardness, and plasticity of the NP-PUs were higher than for pure PU and increased with decreasing soft segment content. Decreased soft segment content induced higher microphase separation, increased hydrophilicity and swelling ability, but decreased cross-linking density. Additionally, NP-PUs had higher glass transition temperatures, improved thermal stability, and enhanced nanomechanical performance over pure PU. The NP-PUs demonstrated good selective inhibition of Candida albicans and Candida parapsilosis (30–55%) and no pronounced cytotoxicity to MRC5 human lung fibroblasts. Among the investigated AgFeO2@PEG/PUs, the best antifungal activity was shown by composites with 30 and 40 wt% soft segments. Consequently, the novel AgFeO2@PEG/polyurethane network nanocomposites could be further optimized to be used as biocompatible surfaces that also prevent formation of fungal biofilms. PB - Springer T2 - Journal of Materials Science T1 - Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites VL - 57 IS - 16 SP - 7827 EP - 7848 DO - 10.1007/s10853-022-07178-9 ER -
@article{ author = "Pergal, Marija and Dojčinović, Biljana and Nikodinović-Runić, Jasmina and Dražić, Goran and Zabukovec Logar, Nataša and Ostojić, Sanja and Antić, Bratislav", year = "2022", abstract = "In situ polymerization was used to produce novel AgFeO2@PEG/polyurethane network nanocomposites (NP-PUs) with 30–60 wt% of soft poly(dimethylsiloxane) segments in polyurethane (PU), containing 1 wt% of PEG-coated AgFeO2 nanoparticles, AgFeO2@PEG. Physicochemical properties and in vitro biological activity of the NP-PUs were systematically evaluated in terms of AgFeO2@PEG (NP) addition and soft segment content. High-angle annular dark-field transmission electron microscopy showed that the nanoparticles were generally uniformly distributed in the PU matrix. Increased soft segment content caused significantly increased intensity of the broad, amorphous X-ray diffraction peaks of crystalline AgFeO2, probably because the chemical composition of PU affected the distribution of nanoparticles. The Young modulus, hardness, and plasticity of the NP-PUs were higher than for pure PU and increased with decreasing soft segment content. Decreased soft segment content induced higher microphase separation, increased hydrophilicity and swelling ability, but decreased cross-linking density. Additionally, NP-PUs had higher glass transition temperatures, improved thermal stability, and enhanced nanomechanical performance over pure PU. The NP-PUs demonstrated good selective inhibition of Candida albicans and Candida parapsilosis (30–55%) and no pronounced cytotoxicity to MRC5 human lung fibroblasts. Among the investigated AgFeO2@PEG/PUs, the best antifungal activity was shown by composites with 30 and 40 wt% soft segments. Consequently, the novel AgFeO2@PEG/polyurethane network nanocomposites could be further optimized to be used as biocompatible surfaces that also prevent formation of fungal biofilms.", publisher = "Springer", journal = "Journal of Materials Science", title = "Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites", volume = "57", number = "16", pages = "7827-7848", doi = "10.1007/s10853-022-07178-9" }
Pergal, M., Dojčinović, B., Nikodinović-Runić, J., Dražić, G., Zabukovec Logar, N., Ostojić, S.,& Antić, B.. (2022). Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites. in Journal of Materials Science Springer., 57(16), 7827-7848. https://doi.org/10.1007/s10853-022-07178-9
Pergal M, Dojčinović B, Nikodinović-Runić J, Dražić G, Zabukovec Logar N, Ostojić S, Antić B. Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites. in Journal of Materials Science. 2022;57(16):7827-7848. doi:10.1007/s10853-022-07178-9 .
Pergal, Marija, Dojčinović, Biljana, Nikodinović-Runić, Jasmina, Dražić, Goran, Zabukovec Logar, Nataša, Ostojić, Sanja, Antić, Bratislav, "Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites" in Journal of Materials Science, 57, no. 16 (2022):7827-7848, https://doi.org/10.1007/s10853-022-07178-9 . .