Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites
Samo za registrovane korisnike
2022
Autori
Šuljagić, MarijaMilenković, Milica
Uskoković, Vuk
Mirković, Miljana
Vrbica, Boško
Pavlović, Vladimir B.
Živković-Radovanović, Vukosava
Stanković, Dalibor
Anđelković, Ljubica
Članak u časopisu (Objavljena verzija)
,
Elsevier
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The emerging threat of bacterial resistance to antibiotics prompts the urgent search for biomaterials for the treatment of infectious disease. Here we report on the synthesis and characterization of a multiphasic nanocomposite comprising magnetic iron oxide and silver nanoparticles. The method of synthesis involved the combustion of a metalorganic complex and reduction of the silver ions that were exchanged and/or adsorbed on the surface of iron oxide. Different physical and chemical treatments coupled to the reduction process, including ultrasound and Lugol's iodine solution, respectively, homogenized the distribution of the silver nanoparticles on the iron oxide phase. Remarkably, using ascorbic acid as a reductant enhanced the magnetic properties of the material as a result of the reduction of the magnetic matrix alongside the silver cations. The treatment with ultrasound detached large amounts of silver from the iron oxide phase and resulted in the lowest amount of silver incorpora...ted in the nanocomposite. Despite that, this treatment led to the highest antibacterial activity against both Gram-positive and Gram-negative strains, indicating that the homogeneity of the distribution of silver on the iron oxide matrix is a more important determinant of the antibacterial performance than the amount of silver incorporated in the material. At the same time, the treatment with Lugol's iodine equally increased the distribution homogeneity, but induced excessive ion exchange and crystal lattice substitutions, thereby adversely affecting the antibacterial performance. This has indicated that the mode of binding silver to iron oxide can compensate for the positive effects of homogeneous distribution with respect to the antibacterial performance.
Ključne reči:
Iron oxide/Ag nanocomposites / Bactericidal effect / Ultrasound treatmentIzvor:
Materials Today Communications, 2022, 32, 104157-Izdavač:
- Elsevier
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200026 (Univerzitet u Beogradu, Institut za hemiju, tehnologiju i metalurgiju - IHTM) (RS-MESTD-inst-2020-200026)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200168 (Univerzitet u Beogradu, Hemijski fakultet) (RS-MESTD-inst-2020-200168)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200116 (Univerzitet u Beogradu, Poljoprivredni fakultet) (RS-MESTD-inst-2020-200116)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (RS-MESTD-inst-2020-200017)
Institucija/grupa
IHTMTY - JOUR AU - Šuljagić, Marija AU - Milenković, Milica AU - Uskoković, Vuk AU - Mirković, Miljana AU - Vrbica, Boško AU - Pavlović, Vladimir B. AU - Živković-Radovanović, Vukosava AU - Stanković, Dalibor AU - Anđelković, Ljubica PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5329 AB - The emerging threat of bacterial resistance to antibiotics prompts the urgent search for biomaterials for the treatment of infectious disease. Here we report on the synthesis and characterization of a multiphasic nanocomposite comprising magnetic iron oxide and silver nanoparticles. The method of synthesis involved the combustion of a metalorganic complex and reduction of the silver ions that were exchanged and/or adsorbed on the surface of iron oxide. Different physical and chemical treatments coupled to the reduction process, including ultrasound and Lugol's iodine solution, respectively, homogenized the distribution of the silver nanoparticles on the iron oxide phase. Remarkably, using ascorbic acid as a reductant enhanced the magnetic properties of the material as a result of the reduction of the magnetic matrix alongside the silver cations. The treatment with ultrasound detached large amounts of silver from the iron oxide phase and resulted in the lowest amount of silver incorporated in the nanocomposite. Despite that, this treatment led to the highest antibacterial activity against both Gram-positive and Gram-negative strains, indicating that the homogeneity of the distribution of silver on the iron oxide matrix is a more important determinant of the antibacterial performance than the amount of silver incorporated in the material. At the same time, the treatment with Lugol's iodine equally increased the distribution homogeneity, but induced excessive ion exchange and crystal lattice substitutions, thereby adversely affecting the antibacterial performance. This has indicated that the mode of binding silver to iron oxide can compensate for the positive effects of homogeneous distribution with respect to the antibacterial performance. PB - Elsevier T2 - Materials Today Communications T1 - Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites VL - 32 SP - 104157 DO - 10.1016/j.mtcomm.2022.104157 ER -
@article{ author = "Šuljagić, Marija and Milenković, Milica and Uskoković, Vuk and Mirković, Miljana and Vrbica, Boško and Pavlović, Vladimir B. and Živković-Radovanović, Vukosava and Stanković, Dalibor and Anđelković, Ljubica", year = "2022", abstract = "The emerging threat of bacterial resistance to antibiotics prompts the urgent search for biomaterials for the treatment of infectious disease. Here we report on the synthesis and characterization of a multiphasic nanocomposite comprising magnetic iron oxide and silver nanoparticles. The method of synthesis involved the combustion of a metalorganic complex and reduction of the silver ions that were exchanged and/or adsorbed on the surface of iron oxide. Different physical and chemical treatments coupled to the reduction process, including ultrasound and Lugol's iodine solution, respectively, homogenized the distribution of the silver nanoparticles on the iron oxide phase. Remarkably, using ascorbic acid as a reductant enhanced the magnetic properties of the material as a result of the reduction of the magnetic matrix alongside the silver cations. The treatment with ultrasound detached large amounts of silver from the iron oxide phase and resulted in the lowest amount of silver incorporated in the nanocomposite. Despite that, this treatment led to the highest antibacterial activity against both Gram-positive and Gram-negative strains, indicating that the homogeneity of the distribution of silver on the iron oxide matrix is a more important determinant of the antibacterial performance than the amount of silver incorporated in the material. At the same time, the treatment with Lugol's iodine equally increased the distribution homogeneity, but induced excessive ion exchange and crystal lattice substitutions, thereby adversely affecting the antibacterial performance. This has indicated that the mode of binding silver to iron oxide can compensate for the positive effects of homogeneous distribution with respect to the antibacterial performance.", publisher = "Elsevier", journal = "Materials Today Communications", title = "Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites", volume = "32", pages = "104157", doi = "10.1016/j.mtcomm.2022.104157" }
Šuljagić, M., Milenković, M., Uskoković, V., Mirković, M., Vrbica, B., Pavlović, V. B., Živković-Radovanović, V., Stanković, D.,& Anđelković, L.. (2022). Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites. in Materials Today Communications Elsevier., 32, 104157. https://doi.org/10.1016/j.mtcomm.2022.104157
Šuljagić M, Milenković M, Uskoković V, Mirković M, Vrbica B, Pavlović VB, Živković-Radovanović V, Stanković D, Anđelković L. Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites. in Materials Today Communications. 2022;32:104157. doi:10.1016/j.mtcomm.2022.104157 .
Šuljagić, Marija, Milenković, Milica, Uskoković, Vuk, Mirković, Miljana, Vrbica, Boško, Pavlović, Vladimir B., Živković-Radovanović, Vukosava, Stanković, Dalibor, Anđelković, Ljubica, "Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites" in Materials Today Communications, 32 (2022):104157, https://doi.org/10.1016/j.mtcomm.2022.104157 . .