Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials
Samo za registrovane korisnike
2008
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Of 17 prepared 1,2,4,5-tetraoxacyclohexanes stable to reductive and acidic conditions, 3 of them were more active than artemisinin against CQ and MFQ resistant strain TM91C235 and all compounds were more active in vitro against W2 than against D6 strain. In vivo, amines 10 and 11a cured all mice at higher doses with MCD ≤ 37.5 (mg/kg)/day. Triol 13 was exceptionally active against melanoma (LOX IMVI) and ovarian cancer (IGROV1), both with LC 50 = 60 nM.
Izvor:
Journal of Medicinal Chemistry, 2008, 51, 7, 2261-2266Izdavač:
- American Chemical Society (ACS)
Finansiranje / projekti:
- Peroksidni antimalarici i njihove himere sa hinolinima: sinteza i biološka aktivnost (RS-MESTD-MPN2006-2010-142022)
DOI: 10.1021/jm701417a
ISSN: 0022-2623
PubMed: 18330976
WoS: 000254709100031
Scopus: 2-s2.0-41849117634
Institucija/grupa
IHTMTY - JOUR AU - Opsenica, Igor AU - Opsenica, Dejan AU - Smith, K. S. AU - Milhous, Wilbur K. AU - Šolaja, Bogdan PY - 2008 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/471 AB - Of 17 prepared 1,2,4,5-tetraoxacyclohexanes stable to reductive and acidic conditions, 3 of them were more active than artemisinin against CQ and MFQ resistant strain TM91C235 and all compounds were more active in vitro against W2 than against D6 strain. In vivo, amines 10 and 11a cured all mice at higher doses with MCD ≤ 37.5 (mg/kg)/day. Triol 13 was exceptionally active against melanoma (LOX IMVI) and ovarian cancer (IGROV1), both with LC 50 = 60 nM. PB - American Chemical Society (ACS) T2 - Journal of Medicinal Chemistry T1 - Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials VL - 51 IS - 7 SP - 2261 EP - 2266 DO - 10.1021/jm701417a ER -
@article{ author = "Opsenica, Igor and Opsenica, Dejan and Smith, K. S. and Milhous, Wilbur K. and Šolaja, Bogdan", year = "2008", abstract = "Of 17 prepared 1,2,4,5-tetraoxacyclohexanes stable to reductive and acidic conditions, 3 of them were more active than artemisinin against CQ and MFQ resistant strain TM91C235 and all compounds were more active in vitro against W2 than against D6 strain. In vivo, amines 10 and 11a cured all mice at higher doses with MCD ≤ 37.5 (mg/kg)/day. Triol 13 was exceptionally active against melanoma (LOX IMVI) and ovarian cancer (IGROV1), both with LC 50 = 60 nM.", publisher = "American Chemical Society (ACS)", journal = "Journal of Medicinal Chemistry", title = "Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials", volume = "51", number = "7", pages = "2261-2266", doi = "10.1021/jm701417a" }
Opsenica, I., Opsenica, D., Smith, K. S., Milhous, W. K.,& Šolaja, B.. (2008). Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials. in Journal of Medicinal Chemistry American Chemical Society (ACS)., 51(7), 2261-2266. https://doi.org/10.1021/jm701417a
Opsenica I, Opsenica D, Smith KS, Milhous WK, Šolaja B. Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials. in Journal of Medicinal Chemistry. 2008;51(7):2261-2266. doi:10.1021/jm701417a .
Opsenica, Igor, Opsenica, Dejan, Smith, K. S., Milhous, Wilbur K., Šolaja, Bogdan, "Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials" in Journal of Medicinal Chemistry, 51, no. 7 (2008):2261-2266, https://doi.org/10.1021/jm701417a . .