Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands
Samo za registrovane korisnike
1991
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and t rifluoroacetamide (VI) of the corresponding 1,2-pheny-lenediamiane were synthesized and tested for DA-ergic activity. III and IV had a moderate affini ty for the D2 receptors of the bovine caudate nucleus. Several potential DA-receptor ligands were synthesized. III and IV expressed the affinity for the D-2 receptor.
Ključne reči:
dopamine / drug synthesis / drug receptor binding / D-2 receptorIzvor:
Bioorganic and Medicinal Chemistry Letters, 1991, 1, 8, 403-406Izdavač:
- Elsevier
Finansiranje / projekti:
- The Research Science Funds of Serbia, Grant No. 8016.
DOI: 10.1016/S0960-894X(00)80265-6
ISSN: 0960-894X; 1464-3405
Scopus: 2-s2.0-0026002989
Institucija/grupa
IHTMTY - JOUR AU - Kostić, Slađana AU - Šoškić, Vukić AU - Joksimović, Jelena PY - 1991 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4384 AB - Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and t rifluoroacetamide (VI) of the corresponding 1,2-pheny-lenediamiane were synthesized and tested for DA-ergic activity. III and IV had a moderate affini ty for the D2 receptors of the bovine caudate nucleus. Several potential DA-receptor ligands were synthesized. III and IV expressed the affinity for the D-2 receptor. PB - Elsevier T2 - Bioorganic and Medicinal Chemistry Letters T1 - Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands VL - 1 IS - 8 SP - 403 EP - 406 DO - 10.1016/S0960-894X(00)80265-6 ER -
@article{ author = "Kostić, Slađana and Šoškić, Vukić and Joksimović, Jelena", year = "1991", abstract = "Derivatives of benzimidazole (I), benzimidazolone (II), benzimidazolethione (III), 2,3-dihydroxyquinoxaline (IV) and the noncyclic acetamide (V) and t rifluoroacetamide (VI) of the corresponding 1,2-pheny-lenediamiane were synthesized and tested for DA-ergic activity. III and IV had a moderate affini ty for the D2 receptors of the bovine caudate nucleus. Several potential DA-receptor ligands were synthesized. III and IV expressed the affinity for the D-2 receptor.", publisher = "Elsevier", journal = "Bioorganic and Medicinal Chemistry Letters", title = "Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands", volume = "1", number = "8", pages = "403-406", doi = "10.1016/S0960-894X(00)80265-6" }
Kostić, S., Šoškić, V.,& Joksimović, J.. (1991). Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands. in Bioorganic and Medicinal Chemistry Letters Elsevier., 1(8), 403-406. https://doi.org/10.1016/S0960-894X(00)80265-6
Kostić S, Šoškić V, Joksimović J. Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands. in Bioorganic and Medicinal Chemistry Letters. 1991;1(8):403-406. doi:10.1016/S0960-894X(00)80265-6 .
Kostić, Slađana, Šoškić, Vukić, Joksimović, Jelena, "Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands" in Bioorganic and Medicinal Chemistry Letters, 1, no. 8 (1991):403-406, https://doi.org/10.1016/S0960-894X(00)80265-6 . .