Приказ основних података о документу
Cholesterol bound to hemoglobin in normal human erythrocytes: a new form of cholesterol in circulation?
dc.creator | Nikolić, Milan | |
dc.creator | Stanić, Dragana | |
dc.creator | Antonijevic, Nadežda | |
dc.creator | Niketić, Vesna | |
dc.date.accessioned | 2021-01-28T15:47:29Z | |
dc.date.available | 2021-01-28T15:47:29Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/4167 | |
dc.description.abstract | Objective: To study lipid fraction that is occasionally observed in red blood cell (RBC) hemolysate (supernatants from which membranes were separated). Study design: Plasma lipid profiles, cholesterol (Ch) and phospholipids (PL) in intact RBCs, RBC membranes and hemolysates were examined in young healthy male population in winter and summer. Results: The RBC Ch and PL content was significantly higher than in membranes, both in winter and summer. The "excess" of cholesterol (associated with phospholipid) was bound to hemoglobin yielding Hb-lipid adduct (Hb-Ch), the pools in the RBC membrane remaining virtually unaltered. Levels of hemoglobin- lipid complex (Hb-Ch), which were significantly higher in winter than in summer (30% and 19% of the total Hb, respectively), positively correlated with plasma HDL cholesterol levels. Conclusion: To our knowledge, this is the first demonstration of cholesterol binding to Hb. The results suggest influence of plasma lipoprotein metabolism on the formation of Hb-Ch. (C) 2003 The Canadian Society of Clinical Chemists. All rights reserved. | en |
dc.publisher | Elsevier | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | cholesterol | en |
dc.subject | HDL cholesterol | en |
dc.subject | hemoglobin | en |
dc.subject | red blood cells | en |
dc.subject | hemoglobin-lipid | en |
dc.subject | seasonal variation | en |
dc.title | Cholesterol bound to hemoglobin in normal human erythrocytes: a new form of cholesterol in circulation? | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Никетиц, Весна; Aнтонијевиц, Надежда; Станић, Драгана; Николић, Милан; | |
dc.citation.volume | 37 | |
dc.citation.issue | 1 | |
dc.citation.spage | 22 | |
dc.citation.epage | 26 | |
dc.citation.other | 37(1): 22-26 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 14675558 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2003.10.002 | |
dc.identifier.scopus | 2-s2.0-0348111560 | |
dc.identifier.wos | 000187580700004 | |
dc.type.version | publishedVersion | en |