Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity
Autori
Stojičkov, MarkoSturm, Sabrina
Čobeljić, Božidar
Pevec, Andrej
Jevtović, Mima
Scheitler, Andreas
Radanović, Dušanka
Senft, Laura
Turel, Iztok
Anđelković, Katarina
Miehlich, Matthias
Meyer, Karsten
Ivanović‐Burmazović, Ivana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We have synthesized and characterized Co(II) (1), Zn(II) (2), Fe(III) (3) and Cu(II) (4) complexes of 2,2'‐[2,6‐pyridinediylbis(ethylidyne‐1‐hydrazinyl‐2‐ylidene)]bis[N,N,N‐trimethyl‐2‐oxoethanaminium] dichloride (H2LCl2) by NMR, IR, and X‐Band EPR spectroscopy, respectively, as well as by single‐crystal X‐ray structural analysis. H2LCl2 belongs to the class of diacetylpyridine bis(hydrazone) ligands and bears two positively charged quaternary ammonium functionalities. The complexes 1–3 possess a pentagonal‐bipyramidal geometry, whereas 4 has square‐pyramidal geometry. Redox reactivity and SOD activity of the complexes was studied by means of electrochemical measurements in aqueous‐buffer and DMF or DMSO solutions, respectively, as well as by stopped‐flow measurements. Complexes 1–3 do not have SOD activity, whereas 4 exhibits a high catalytic rate constant for the superoxide dismutation, kcat = 1.73 × 107 m–1 s–1 (in MOPS buffer solution of pH = 7.4). The results were discussed in ter...ms of complex redox potentials, electrostatic interactions and their spatial distribution, kinetic lability of metal centers, and stability of peroxo intermediates, respectively.
Ključne reči:
Cobalt / Copper / Electrochemistry / Iron / SOD activity / Structure elucidationIzvor:
European Journal of Inorganic Chemistry, 2020, 3347-3358Izdavač:
- Wiley-VCH Verlag
Finansiranje / projekti:
- Interakcije prirodnih proizvoda, njihovih derivata i kompleksnih jedinjenja sa proteinima i nukleinskim kiselinama (RS-MESTD-Basic Research (BR or ON)-172055)
- Slovenian Research Agency (ARRS) through program P‐0175
- ERASMUS + program
- DFG (IV 80/13‐1 project)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200026 (Univerzitet u Beogradu, Institut za hemiju, tehnologiju i metalurgiju - IHTM) (RS-MESTD-inst-2020-200026)
DOI: 10.1002/ejic.202000415
ISSN: 1099-0682
WoS: 000564577200001
Scopus: 2-s2.0-85090058906
URI
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejic.202000415https://cer.ihtm.bg.ac.rs/handle/123456789/3712
Institucija/grupa
IHTMTY - JOUR AU - Stojičkov, Marko AU - Sturm, Sabrina AU - Čobeljić, Božidar AU - Pevec, Andrej AU - Jevtović, Mima AU - Scheitler, Andreas AU - Radanović, Dušanka AU - Senft, Laura AU - Turel, Iztok AU - Anđelković, Katarina AU - Miehlich, Matthias AU - Meyer, Karsten AU - Ivanović‐Burmazović, Ivana PY - 2020 UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejic.202000415 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3712 AB - We have synthesized and characterized Co(II) (1), Zn(II) (2), Fe(III) (3) and Cu(II) (4) complexes of 2,2'‐[2,6‐pyridinediylbis(ethylidyne‐1‐hydrazinyl‐2‐ylidene)]bis[N,N,N‐trimethyl‐2‐oxoethanaminium] dichloride (H2LCl2) by NMR, IR, and X‐Band EPR spectroscopy, respectively, as well as by single‐crystal X‐ray structural analysis. H2LCl2 belongs to the class of diacetylpyridine bis(hydrazone) ligands and bears two positively charged quaternary ammonium functionalities. The complexes 1–3 possess a pentagonal‐bipyramidal geometry, whereas 4 has square‐pyramidal geometry. Redox reactivity and SOD activity of the complexes was studied by means of electrochemical measurements in aqueous‐buffer and DMF or DMSO solutions, respectively, as well as by stopped‐flow measurements. Complexes 1–3 do not have SOD activity, whereas 4 exhibits a high catalytic rate constant for the superoxide dismutation, kcat = 1.73 × 107 m–1 s–1 (in MOPS buffer solution of pH = 7.4). The results were discussed in terms of complex redox potentials, electrostatic interactions and their spatial distribution, kinetic lability of metal centers, and stability of peroxo intermediates, respectively. PB - Wiley-VCH Verlag T2 - European Journal of Inorganic Chemistry T1 - Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity SP - 3347 EP - 3358 DO - 10.1002/ejic.202000415 ER -
@article{ author = "Stojičkov, Marko and Sturm, Sabrina and Čobeljić, Božidar and Pevec, Andrej and Jevtović, Mima and Scheitler, Andreas and Radanović, Dušanka and Senft, Laura and Turel, Iztok and Anđelković, Katarina and Miehlich, Matthias and Meyer, Karsten and Ivanović‐Burmazović, Ivana", year = "2020", abstract = "We have synthesized and characterized Co(II) (1), Zn(II) (2), Fe(III) (3) and Cu(II) (4) complexes of 2,2'‐[2,6‐pyridinediylbis(ethylidyne‐1‐hydrazinyl‐2‐ylidene)]bis[N,N,N‐trimethyl‐2‐oxoethanaminium] dichloride (H2LCl2) by NMR, IR, and X‐Band EPR spectroscopy, respectively, as well as by single‐crystal X‐ray structural analysis. H2LCl2 belongs to the class of diacetylpyridine bis(hydrazone) ligands and bears two positively charged quaternary ammonium functionalities. The complexes 1–3 possess a pentagonal‐bipyramidal geometry, whereas 4 has square‐pyramidal geometry. Redox reactivity and SOD activity of the complexes was studied by means of electrochemical measurements in aqueous‐buffer and DMF or DMSO solutions, respectively, as well as by stopped‐flow measurements. Complexes 1–3 do not have SOD activity, whereas 4 exhibits a high catalytic rate constant for the superoxide dismutation, kcat = 1.73 × 107 m–1 s–1 (in MOPS buffer solution of pH = 7.4). The results were discussed in terms of complex redox potentials, electrostatic interactions and their spatial distribution, kinetic lability of metal centers, and stability of peroxo intermediates, respectively.", publisher = "Wiley-VCH Verlag", journal = "European Journal of Inorganic Chemistry", title = "Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity", pages = "3347-3358", doi = "10.1002/ejic.202000415" }
Stojičkov, M., Sturm, S., Čobeljić, B., Pevec, A., Jevtović, M., Scheitler, A., Radanović, D., Senft, L., Turel, I., Anđelković, K., Miehlich, M., Meyer, K.,& Ivanović‐Burmazović, I.. (2020). Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity. in European Journal of Inorganic Chemistry Wiley-VCH Verlag., 3347-3358. https://doi.org/10.1002/ejic.202000415
Stojičkov M, Sturm S, Čobeljić B, Pevec A, Jevtović M, Scheitler A, Radanović D, Senft L, Turel I, Anđelković K, Miehlich M, Meyer K, Ivanović‐Burmazović I. Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity. in European Journal of Inorganic Chemistry. 2020;:3347-3358. doi:10.1002/ejic.202000415 .
Stojičkov, Marko, Sturm, Sabrina, Čobeljić, Božidar, Pevec, Andrej, Jevtović, Mima, Scheitler, Andreas, Radanović, Dušanka, Senft, Laura, Turel, Iztok, Anđelković, Katarina, Miehlich, Matthias, Meyer, Karsten, Ivanović‐Burmazović, Ivana, "Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity" in European Journal of Inorganic Chemistry (2020):3347-3358, https://doi.org/10.1002/ejic.202000415 . .