Приказ основних података о документу
Two new phenylpiperazines with atypical antipsychotic potential
dc.creator | Tomić, Mirko | |
dc.creator | Ignjatović, D. | |
dc.creator | Tovilović, Gordana | |
dc.creator | Andrić, Deana | |
dc.creator | Roglić, Goran | |
dc.creator | Kostić Rajačić, Slađana | |
dc.date.accessioned | 2019-01-30T17:16:27Z | |
dc.date.available | 2019-01-30T17:16:27Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0960-894X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/354 | |
dc.description.abstract | Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D2, 5-HT1A, 5-HT2A, and α1-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D2 pKi binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized d-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency. | en |
dc.publisher | Oxford : Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143032/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142009/RS// | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic and Medicinal Chemistry Letters | |
dc.subject | Arylpiperazines | en |
dc.subject | Atypical antipsychotics | en |
dc.subject | Dopamine receptors | en |
dc.subject | Serotonin receptors | en |
dc.title | Two new phenylpiperazines with atypical antipsychotic potential | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Костић Рајачић, Слађана; Aндрић, Д.; Томић, М.; Товиловић, Г.; Роглић, Г.; Игњатовић, Д.; | |
dc.citation.volume | 17 | |
dc.citation.issue | 21 | |
dc.citation.spage | 5749 | |
dc.citation.epage | 5753 | |
dc.citation.other | 17(21): 5749-5753 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 17870534 | |
dc.identifier.doi | 10.1016/j.bmcl.2007.08.066 | |
dc.identifier.scopus | 2-s2.0-34648847078 | |
dc.identifier.wos | 000250287800003 | |
dc.type.version | publishedVersion |