Role of complexes formation between drugs and penetration enhancers in transdermal delivery
Samo za registrovane korisnike
2008
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects. Crown Copyright
Ključne reči:
Conformational search / Small molecule-small molecule / interactions / Transdermal delivery / Penetration enhancersIzvor:
International Journal of Pharmaceutics, 2008, 363, 1-2, 40-49Izdavač:
- Elsevier
Finansiranje / projekti:
- Sinteza, karakterizacija i aktivnost organskih i koordinacionih jedinjenja i njihova primena u (bio)nanotehnologiji (RS-MESTD-MPN2006-2010-142010)
DOI: 10.1016/j.ijpharm.2008.06.032
ISSN: 0378-5173
PubMed: 18675333
WoS: 000260478700003
Scopus: 2-s2.0-51749091289
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/1029https://cer.ihtm.bg.ac.rs/handle/123456789/3512
Institucija/grupa
IHTMTY - JOUR AU - Drakulić, Branko AU - Juranić, Ivan AU - Erić, Slavica AU - Zloh, Mire PY - 2008 UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/1029 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3512 AB - The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects. Crown Copyright PB - Elsevier T2 - International Journal of Pharmaceutics T1 - Role of complexes formation between drugs and penetration enhancers in transdermal delivery VL - 363 IS - 1-2 SP - 40 EP - 49 DO - 10.1016/j.ijpharm.2008.06.032 ER -
@article{ author = "Drakulić, Branko and Juranić, Ivan and Erić, Slavica and Zloh, Mire", year = "2008", abstract = "The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects. Crown Copyright", publisher = "Elsevier", journal = "International Journal of Pharmaceutics", title = "Role of complexes formation between drugs and penetration enhancers in transdermal delivery", volume = "363", number = "1-2", pages = "40-49", doi = "10.1016/j.ijpharm.2008.06.032" }
Drakulić, B., Juranić, I., Erić, S.,& Zloh, M.. (2008). Role of complexes formation between drugs and penetration enhancers in transdermal delivery. in International Journal of Pharmaceutics Elsevier., 363(1-2), 40-49. https://doi.org/10.1016/j.ijpharm.2008.06.032
Drakulić B, Juranić I, Erić S, Zloh M. Role of complexes formation between drugs and penetration enhancers in transdermal delivery. in International Journal of Pharmaceutics. 2008;363(1-2):40-49. doi:10.1016/j.ijpharm.2008.06.032 .
Drakulić, Branko, Juranić, Ivan, Erić, Slavica, Zloh, Mire, "Role of complexes formation between drugs and penetration enhancers in transdermal delivery" in International Journal of Pharmaceutics, 363, no. 1-2 (2008):40-49, https://doi.org/10.1016/j.ijpharm.2008.06.032 . .