Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats
Samo za registrovane korisnike
2020
Autori
Đurašević, SinišaNikolić, Gorana
Todorović, Ana
Drakulić, Dunja
Pejić, Snežana
Martinović, Vesna
Mitić-Ćulafić, Dragana
Milić, Dragana
Kop, Tatjana
Jasnić, Nebojša
Đorđević, Jelena
Todorović, Zoran
Članak u časopisu (Objavljena verzija)
,
Elsevier
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, ...and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.
Ključne reči:
Fullerene C60 / Glucose homeostasis / Lipid homeostasis / Gut microbiota / RatsIzvor:
Food and Chemical Toxicology, 2020, 140, 111322-Izdavač:
- Elsevier
Finansiranje / projekti:
- Efekat metaboličkih i nemetaboličkih stresora na ekspresiju i delovanje neuroendokrinih regulatora energetske homeostaze (RS-173023)
- Signalni molekuli u dijabetesu: identifikacija potencijalnih bioloških markera uključenih u modifikaciju i integraciju signalnih puteva u cilju predikcije i intervencije u dijabetesu (RS-173020)
- Dizajn, sinteza i ispitivanje nanomolekulskih mašina na bazi fulerena (RS-172002)
- Biološki aktivni prirodni proizvodi kao potencijalni izvori novih lekova i dijetetskih suplemenata (RS-172058)
- Ćelijske i molekulske osnove malignih i kardiovaskularnih oboljenja-kliničke implikacije (RS-41027)
DOI: 10.1016/j.fct.2020.111302
ISSN: 0278-6915
WoS: 000535895100014
Scopus: 2-s2.0-85082680875
Institucija/grupa
IHTMTY - JOUR AU - Đurašević, Siniša AU - Nikolić, Gorana AU - Todorović, Ana AU - Drakulić, Dunja AU - Pejić, Snežana AU - Martinović, Vesna AU - Mitić-Ćulafić, Dragana AU - Milić, Dragana AU - Kop, Tatjana AU - Jasnić, Nebojša AU - Đorđević, Jelena AU - Todorović, Zoran PY - 2020 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3488 AB - The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action. PB - Elsevier T2 - Food and Chemical Toxicology T1 - Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats VL - 140 SP - 111322 DO - 10.1016/j.fct.2020.111302 ER -
@article{ author = "Đurašević, Siniša and Nikolić, Gorana and Todorović, Ana and Drakulić, Dunja and Pejić, Snežana and Martinović, Vesna and Mitić-Ćulafić, Dragana and Milić, Dragana and Kop, Tatjana and Jasnić, Nebojša and Đorđević, Jelena and Todorović, Zoran", year = "2020", abstract = "The effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.", publisher = "Elsevier", journal = "Food and Chemical Toxicology", title = "Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats", volume = "140", pages = "111322", doi = "10.1016/j.fct.2020.111302" }
Đurašević, S., Nikolić, G., Todorović, A., Drakulić, D., Pejić, S., Martinović, V., Mitić-Ćulafić, D., Milić, D., Kop, T., Jasnić, N., Đorđević, J.,& Todorović, Z.. (2020). Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. in Food and Chemical Toxicology Elsevier., 140, 111322. https://doi.org/10.1016/j.fct.2020.111302
Đurašević S, Nikolić G, Todorović A, Drakulić D, Pejić S, Martinović V, Mitić-Ćulafić D, Milić D, Kop T, Jasnić N, Đorđević J, Todorović Z. Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats. in Food and Chemical Toxicology. 2020;140:111322. doi:10.1016/j.fct.2020.111302 .
Đurašević, Siniša, Nikolić, Gorana, Todorović, Ana, Drakulić, Dunja, Pejić, Snežana, Martinović, Vesna, Mitić-Ćulafić, Dragana, Milić, Dragana, Kop, Tatjana, Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran, "Effects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in rats" in Food and Chemical Toxicology, 140 (2020):111322, https://doi.org/10.1016/j.fct.2020.111302 . .