Electrochemical and spectroscopic study of l‑dopa interaction with avarol
Само за регистроване кориснике
2019
Чланак у часопису (Објављена верзија)
,
Springer
Метаподаци
Приказ свих података о документуАпстракт
The electrochemistry of catecholamine neurotransmitters and their precursor l-dopa has been widely studied due to their relevance as biologically important compounds. The detection of these compounds from aqueous solution is hindered by the coexistence of quinone or hydroquinone. However, it was suggested that quinones adsorbed on the electrode surface can enhance catechol detection. In order to estimate the degree of interaction between quinones and l-dopa, cyclic voltammetry and UV-Vis spectroscopic study was performed. A sesquiterpenoid hydroquinone, isolated from the marine sponge Dysidea avara (avarol), has been used in this study. The change of apparent heterogeneous rate constant with different avarol/l-dopa ratio indicated that charge transfer could be enhanced at some extent. In addition to this, the obtained results for avarol and hydroquinone (its structural element) were compared. UV-Vis spectroscopic analysis confirmed interaction between l-dopa and avarol or hydroquinone.... Taken all together, the interaction of l-dopa was stronger with hydroquinone than with avarol, presumably reflecting the conformational restrains of avarol caused by its terpenoid moiety.
Кључне речи:
Avarol / l-dopa / Hydroquinone / Cyclic voltammetry / UV-VisИзвор:
Reaction Kinetics, Mechanisms and Catalysis, 2019, 127, 1, 219-229Издавач:
- Springer
Финансирање / пројекти:
- Наноструктурни функционални и композитни материјали у каталитичким и сорпционим процесима (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45001)
- Биомаркери у неуродегенеративним и малигним процесима (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41005)
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
DOI: 10.1007/s11144-019-01575-z
ISSN: 1878-5190; 1878-5204
WoS: 000468213500017
Scopus: 2-s2.0-85064334278
Институција/група
IHTMTY - JOUR AU - Nakarada, Đura AU - Pejin, Boris AU - Dimić, Dušan AU - Ivanović-Šašić, Ana AU - Mojović, Zorica AU - Mojović, Miloš PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/3027 AB - The electrochemistry of catecholamine neurotransmitters and their precursor l-dopa has been widely studied due to their relevance as biologically important compounds. The detection of these compounds from aqueous solution is hindered by the coexistence of quinone or hydroquinone. However, it was suggested that quinones adsorbed on the electrode surface can enhance catechol detection. In order to estimate the degree of interaction between quinones and l-dopa, cyclic voltammetry and UV-Vis spectroscopic study was performed. A sesquiterpenoid hydroquinone, isolated from the marine sponge Dysidea avara (avarol), has been used in this study. The change of apparent heterogeneous rate constant with different avarol/l-dopa ratio indicated that charge transfer could be enhanced at some extent. In addition to this, the obtained results for avarol and hydroquinone (its structural element) were compared. UV-Vis spectroscopic analysis confirmed interaction between l-dopa and avarol or hydroquinone. Taken all together, the interaction of l-dopa was stronger with hydroquinone than with avarol, presumably reflecting the conformational restrains of avarol caused by its terpenoid moiety. PB - Springer T2 - Reaction Kinetics, Mechanisms and Catalysis T1 - Electrochemical and spectroscopic study of l‑dopa interaction with avarol VL - 127 IS - 1 SP - 219 EP - 229 DO - 10.1007/s11144-019-01575-z ER -
@article{ author = "Nakarada, Đura and Pejin, Boris and Dimić, Dušan and Ivanović-Šašić, Ana and Mojović, Zorica and Mojović, Miloš", year = "2019", abstract = "The electrochemistry of catecholamine neurotransmitters and their precursor l-dopa has been widely studied due to their relevance as biologically important compounds. The detection of these compounds from aqueous solution is hindered by the coexistence of quinone or hydroquinone. However, it was suggested that quinones adsorbed on the electrode surface can enhance catechol detection. In order to estimate the degree of interaction between quinones and l-dopa, cyclic voltammetry and UV-Vis spectroscopic study was performed. A sesquiterpenoid hydroquinone, isolated from the marine sponge Dysidea avara (avarol), has been used in this study. The change of apparent heterogeneous rate constant with different avarol/l-dopa ratio indicated that charge transfer could be enhanced at some extent. In addition to this, the obtained results for avarol and hydroquinone (its structural element) were compared. UV-Vis spectroscopic analysis confirmed interaction between l-dopa and avarol or hydroquinone. Taken all together, the interaction of l-dopa was stronger with hydroquinone than with avarol, presumably reflecting the conformational restrains of avarol caused by its terpenoid moiety.", publisher = "Springer", journal = "Reaction Kinetics, Mechanisms and Catalysis", title = "Electrochemical and spectroscopic study of l‑dopa interaction with avarol", volume = "127", number = "1", pages = "219-229", doi = "10.1007/s11144-019-01575-z" }
Nakarada, Đ., Pejin, B., Dimić, D., Ivanović-Šašić, A., Mojović, Z.,& Mojović, M.. (2019). Electrochemical and spectroscopic study of l‑dopa interaction with avarol. in Reaction Kinetics, Mechanisms and Catalysis Springer., 127(1), 219-229. https://doi.org/10.1007/s11144-019-01575-z
Nakarada Đ, Pejin B, Dimić D, Ivanović-Šašić A, Mojović Z, Mojović M. Electrochemical and spectroscopic study of l‑dopa interaction with avarol. in Reaction Kinetics, Mechanisms and Catalysis. 2019;127(1):219-229. doi:10.1007/s11144-019-01575-z .
Nakarada, Đura, Pejin, Boris, Dimić, Dušan, Ivanović-Šašić, Ana, Mojović, Zorica, Mojović, Miloš, "Electrochemical and spectroscopic study of l‑dopa interaction with avarol" in Reaction Kinetics, Mechanisms and Catalysis, 127, no. 1 (2019):219-229, https://doi.org/10.1007/s11144-019-01575-z . .