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Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application
dc.creator | Nikolić, Ines | |
dc.creator | Lunter, Dominique Jasmin | |
dc.creator | Randjelović, Danijela | |
dc.creator | Žugić, Ana | |
dc.creator | Tadić, Vanja | |
dc.creator | Marković, Bojan D. | |
dc.creator | Cekic, Nebojsa | |
dc.creator | Živković, Lada | |
dc.creator | Topalovic, Dijana | |
dc.creator | Spremo-Potparević, Biljana | |
dc.creator | Daniels, Rolf | |
dc.creator | Savić, Snežana D. | |
dc.date.accessioned | 2019-01-30T18:00:14Z | |
dc.date.available | 2019-01-30T18:00:14Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2425 | |
dc.description.abstract | The objective of this work was to investigate and profoundly characterize low-energy nanoemulsions as multifunctional carriers, with slight reference to dermal administration. An evidence-based approach was offered for deepening the knowledge on their formation via spontaneous emulsification. Curcumin, a compound of natural origin, potentially powerful therapeutic, was chosen as a model API. Due to curcumin's demanding properties (instability, poor solubility, low permeability), its potentials remain unreached. Low-energy nanoemulsions were considered carriers capable of overcoming imposed obstacles. Formulation consisting of Polysorbate 80 and soybean lecithin as stabilizers (9:1, 10%), medium-chain triglycerides as the oil phase (10%) and ultrapure water was selected for curcumin incorporation in 3 different concentrations (1, 2 and 3 mg/mL). Physicochemical stability was demonstrated during 3 months of monitoring (mean droplet size: 111.3-146.8 nm; PDI LT 0.2; pH: 4.73-5.73). Curcumin's release from developed vehicles followed Higuchi's kinetics. DPPH (IC50 = 0.1187 mg/ mL) and FRAP (1.19 +/- 0.02 mmol/g) assays confirmed that curcumin acts as a potent antioxidant through different mechanisms, with no alterations after incorporation in the formulation. High biocompatibility in line with antigenotoxic activity of curcumin-loaded formulations (protective and reparative) was estimated through Comet assay. A multidisciplinary approach is needed to fully characterize developed systems, directing them to more concrete application possibilities. | en |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS// | |
dc.relation | Republic of Serbia | |
dc.relation | Federal Republic of Germany | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS// | |
dc.rights | restrictedAccess | |
dc.source | International Journal of Pharmaceutics | |
dc.subject | Low-energy nanoemulsions | en |
dc.subject | Spontaneous emulsification | en |
dc.subject | Curcumin | en |
dc.subject | Atomic force microscopy | en |
dc.subject | Antioxidant activity | en |
dc.subject | (Anti)genotoxicity | en |
dc.title | Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Цекиц, Небојса; Марковиц, Бојан; Тадиц, Вања; Николиц, Инес; Зивковиц, Лада; Спремо-Потпаревиц, Биљана; Даниелс, Ролф; Савиц, Снезана; Лунтер, Доминиqуе Јасмин; Зугиц, Aна; Топаловиц, Дијана; Ранђеловић, Данијела; | |
dc.citation.volume | 550 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 333 | |
dc.citation.epage | 346 | |
dc.citation.other | 550(1-2): 333-346 | |
dc.citation.rank | M21 | |
dc.description.other | The peer-reviewed version: [https://cer.ihtm.bg.ac.rs/handle/123456789/3719] | |
dc.identifier.pmid | 30179702 | |
dc.identifier.doi | 10.1016/j.ijpharm.2018.08.060 | |
dc.identifier.scopus | 2-s2.0-85052734341 | |
dc.identifier.wos | 000445147000033 | |
dc.type.version | publishedVersion |