Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
Samo za registrovane korisnike
2018
Autori
Krstić, GordanaJadranin, Milka
Todorović, Nina
Pešić, Milica
Stankovic, Tijana
Aljančić, Ivana
Tešević, Vele
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.
Ključne reči:
Euphorbia nicaeensis / Euphorbiaceae / Diterpenoids / Jatrophanes / Isolation / Structutre determination / P-glycoprotein / Multi-drug resistanceIzvor:
Phytochemistry, 2018, 148, 104-112Izdavač:
- Oxford : Pergamon-Elsevier Science Ltd
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-172053)
- Identifikacija molekularnih markera za predikciju progresije tumora, odgovora na terapiju i ishoda bolesti (RS-41031)
DOI: 10.1016/j.phytochem.2018.01.016
ISSN: 0031-9422
PubMed: 29421506
WoS: 000427334600013
Scopus: 2-s2.0-85041594265
Institucija/grupa
IHTMTY - JOUR AU - Krstić, Gordana AU - Jadranin, Milka AU - Todorović, Nina AU - Pešić, Milica AU - Stankovic, Tijana AU - Aljančić, Ivana AU - Tešević, Vele PY - 2018 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2319 AB - Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER. PB - Oxford : Pergamon-Elsevier Science Ltd T2 - Phytochemistry T1 - Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis VL - 148 SP - 104 EP - 112 DO - 10.1016/j.phytochem.2018.01.016 ER -
@article{ author = "Krstić, Gordana and Jadranin, Milka and Todorović, Nina and Pešić, Milica and Stankovic, Tijana and Aljančić, Ivana and Tešević, Vele", year = "2018", abstract = "Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.", publisher = "Oxford : Pergamon-Elsevier Science Ltd", journal = "Phytochemistry", title = "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis", volume = "148", pages = "104-112", doi = "10.1016/j.phytochem.2018.01.016" }
Krstić, G., Jadranin, M., Todorović, N., Pešić, M., Stankovic, T., Aljančić, I.,& Tešević, V.. (2018). Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. in Phytochemistry Oxford : Pergamon-Elsevier Science Ltd., 148, 104-112. https://doi.org/10.1016/j.phytochem.2018.01.016
Krstić G, Jadranin M, Todorović N, Pešić M, Stankovic T, Aljančić I, Tešević V. Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. in Phytochemistry. 2018;148:104-112. doi:10.1016/j.phytochem.2018.01.016 .
Krstić, Gordana, Jadranin, Milka, Todorović, Nina, Pešić, Milica, Stankovic, Tijana, Aljančić, Ivana, Tešević, Vele, "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis" in Phytochemistry, 148 (2018):104-112, https://doi.org/10.1016/j.phytochem.2018.01.016 . .