Приказ основних података о документу
Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models
dc.creator | Kolarević, Stoimir M. | |
dc.creator | Milovanović, Dragana | |
dc.creator | Kračun-Kolarević, Margareta | |
dc.creator | Kostić, Jovana | |
dc.creator | Sunjog, K. | |
dc.creator | Martinović, Rajko | |
dc.creator | Đorđević, Jelena | |
dc.creator | Novaković, Irena | |
dc.creator | Sladić, Dušan | |
dc.creator | Vuković-Gačić, Branka | |
dc.date.accessioned | 2019-01-30T17:56:06Z | |
dc.date.available | 2019-01-30T17:56:06Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0148-0545 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2232 | |
dc.description.abstract | In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3′-methoxyavarone, 4′-(methylamino)avarone and 3′-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). Mutagenic potential of selected hydroquinone and quinones was assessed in prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002. Genotoxic potential was also assessed in eukaryotic models using comet assay in human fetal lung cell line (MRC-5), human adenocarcinoma epithelial cell line (A549), and in human peripheral blood cells (HPBC). The results indicated that avarol and avarone do not exert mutagenic/genotoxic potential. Among the studied avarone derivatives, mutagenic potential was detected by SOS/umuC test for 3′-(methylamino)avarone, but only after metabolic activation. The results of comet assay indicated that 3′-methoxyavarone and 3′-(methylamino)avarone have a significant impact on the level of DNA damage in the MRC-5 cell line. Genotoxic potential was not observed in A549 cells or HPBC probably due to a different uptake rate for the compounds and lower in metabolism rate within these cells. | en |
dc.publisher | Taylor and Francis Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS// | |
dc.rights | restrictedAccess | |
dc.source | Drug and Chemical Toxicology | |
dc.subject | Avarol | en |
dc.subject | avarone | en |
dc.subject | comet assay | en |
dc.subject | genotoxicity | en |
dc.subject | mutagenicity | en |
dc.subject | SOS/umuC | en |
dc.title | Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Суњог, К.; Крачун-Коларевић, М.; Миловановић, Д.; Новаковић, Ирена; Вуковић-Гачић, Б.; Ђорђевић, Ј.; Мартиновић, Р.; Сладић, Д.; Коларевић, С.; Костић, Ј.; | |
dc.citation.spage | 1 | |
dc.citation.epage | 10 | |
dc.citation.other | : 1-10 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.1080/01480545.2017.1413108 | |
dc.identifier.scopus | 2-s2.0-85041102861 | |
dc.identifier.wos | 000459818600003 | |
dc.type.version | publishedVersion |