The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity
Само за регистроване кориснике
2017
Аутори
Pejin, BorisTešanović, K.
Jakovljević, Dragica
Kaišarević, S.
Šibul, F.
Rašeta, M.
Karaman, M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.
Кључне речи:
AChE inhibitors of natural origin not belonging to the alkaloids / Alzheimer’s disease / Mushrooms / sugarsИзвор:
Natural Product Research, 2017, 1-5Издавач:
- Taylor and Francis Ltd.
Финансирање / пројекти:
- Симултана биоремедијација и соилификација деградираних простора, за очување природних ресурса биолошки активних супстанци и развој и производњу биоматеријала и дијететских производа (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
- Биолошки активни природни производи као потенцијални извори нових лекова и дијететских суплемената (RS-MESTD-Basic Research (BR or ON)-172058)
DOI: 10.1080/14786419.2017.1405417
ISSN: 1478-6419
WoS: 000466416500021
Scopus: 2-s2.0-85034782445
Институција/група
IHTMTY - JOUR AU - Pejin, Boris AU - Tešanović, K. AU - Jakovljević, Dragica AU - Kaišarević, S. AU - Šibul, F. AU - Rašeta, M. AU - Karaman, M. PY - 2017 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2226 AB - The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease. PB - Taylor and Francis Ltd. T2 - Natural Product Research T1 - The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity SP - 1 EP - 5 DO - 10.1080/14786419.2017.1405417 ER -
@article{ author = "Pejin, Boris and Tešanović, K. and Jakovljević, Dragica and Kaišarević, S. and Šibul, F. and Rašeta, M. and Karaman, M.", year = "2017", abstract = "The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 ± 0.07 and 0.61 ± 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained β-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer’s disease.", publisher = "Taylor and Francis Ltd.", journal = "Natural Product Research", title = "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity", pages = "1-5", doi = "10.1080/14786419.2017.1405417" }
Pejin, B., Tešanović, K., Jakovljević, D., Kaišarević, S., Šibul, F., Rašeta, M.,& Karaman, M.. (2017). The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research Taylor and Francis Ltd.., 1-5. https://doi.org/10.1080/14786419.2017.1405417
Pejin B, Tešanović K, Jakovljević D, Kaišarević S, Šibul F, Rašeta M, Karaman M. The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research. 2017;:1-5. doi:10.1080/14786419.2017.1405417 .
Pejin, Boris, Tešanović, K., Jakovljević, Dragica, Kaišarević, S., Šibul, F., Rašeta, M., Karaman, M., "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity" in Natural Product Research (2017):1-5, https://doi.org/10.1080/14786419.2017.1405417 . .