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In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid
dc.creator | Zmejkovski, Bojana | |
dc.creator | Pantelic, Nebojsa | |
dc.creator | Filipovic, Lana | |
dc.creator | Arandelovic, Sandra | |
dc.creator | Radulovic, Sinisa | |
dc.creator | Sabo, Tibor | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2019-01-30T17:54:06Z | |
dc.date.available | 2019-01-30T17:54:06Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1871-5206 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/2132 | |
dc.description.abstract | Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)(2)eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)(2)eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Method: Quantum chemical calculations were used to predict formed isomers of 1 and 2. Furthermore, reduction of 2 with ascorbic acid was followed by time-dependant C-13 NMR spectroscopy in order to enable assignation of the formed isomers for complex 1. In vitro cytotoxic activity was determined for 1 and 2 on a panel of five human tumor cell lines derived from cervix adenocarcinoma (HeLa), alveolar basal adenocarcinoma (A549), breast adenocarcinoma (MDA-453), colorectal cancer (LS 174), erythromyeloblastoid leukemia (K562), as well as one non-malignant human lung fibroblast cell line (MRC-5), using MTT assay. Result: Both complexes exhibited high (2 against K562: IC50 = 5.4 mu M), more active than cisplatin, to moderate activity (1). Both complexes caused considerable decrease of cell number in K562 cells in G1, S and G2 phases, concordantly increasing subpopulation in sub-G1 fraction. Morphological analysis of K562 cell death induced by platinum(II/IV) complexes indicate apoptosis. | en |
dc.publisher | Bentham Science Publ Ltd, Sharjah | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Anti-Cancer Agents in Medicinal Chemistry | |
dc.subject | Platinum complexes | en |
dc.subject | R(2)eddip ligands | en |
dc.subject | DFT calculations | en |
dc.subject | anticancer activity | en |
dc.subject | apoptosis | en |
dc.subject | cell cycle | en |
dc.title | In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Змејковски, Бојана; Пантелиц, Небојса; Филиповиц, Лана; Aранделовиц, Сандра; Радуловиц, Синиса; Калудеровиц, Горан Н.; Сабо, Тибор Ј.; | |
dc.citation.volume | 17 | |
dc.citation.issue | 8 | |
dc.citation.spage | 1136 | |
dc.citation.epage | 1143 | |
dc.citation.other | 17(8): 1136-1143 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 27928952 | |
dc.identifier.doi | 10.2174/1871520616666161207155634 | |
dc.identifier.scopus | 2-s2.0-85027877786 | |
dc.identifier.wos | 000407271800011 | |
dc.type.version | publishedVersion |
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