The HPA axis and ethanol: a synthesis of mathematical modelling and experimental observations
Samo za registrovane korisnike
2017
Autori
Čupić, ŽeljkoStanojevic, Ana
Marković, Vladimir M.
Kolar-Anić, Ljiljana
Terenius, Lars
Vukojevic, Vladana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Stress and alcohol use are interrelatedstress contributes to the initiation and upholding of alcohol use and alcohol use alters the way we perceive and respond to stress. Intricate mechanisms through which ethanol alters the organism's response to stress remain elusive. We have developed a stoichiometric network model to succinctly describe neurochemical transformations underlying the stress response axis and use numerical simulations to model ethanol effects on complex daily changes of blood levels of cholesterol, 6 peptide and 8 steroid hormones. Modelling suggests that ethanol alters the dynamical regulation of hypothalamic-pituitary-adrenal (HPA) axis activity by affecting the amplitude of ultradian oscillations of HPA axis hormones, which defines the threshold with respect to which the response to stress is being set. These effects are complexlow/moderate acute ethanol challenge ( LT 8mM) may reduce, leave unaltered or increase the amplitude of ultradian cortisol (CORT) oscillati...ons, giving rise to an intricate response at the organism level, offering also a potential explanation as to why apparently discordant results were observed in experimental studies. In contrast, high-dose acute ethanol challenge (> 8mM) increases instantaneous CORT levels and the amplitude of ultradian CORT oscillations in a dose-dependent manner, affecting the HPA axis activity also during the following day(s). Chronic exposure to ethanol qualitatively changes the HPA axis dynamics, whereas ethanol at intoxicating levels shuts down this dynamic regulation mechanism. Mathematical modelling gives a quantitative biology-based framework that can be used for predicting how the integral HPA axis response is perturbed by alcohol.
Ključne reči:
Alcohol or ethanol / blunted HPA axis response / corticotropin-releasing factor or corticotropin-releasing hormone / dynamical systems theory / HPA axis / opioid surfeit / stressIzvor:
Addiction Biology, 2017, 22, 6, 1486-1500Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Karolinska Institute Research Funds
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
- Rajko and Maj Dermanovic Fund
- CMST COST Action CM 1304 'Emergence and Evolution of Complex Chemical Systems'
- Dinamika nelinearnih fizičkohemijskih i biohemijskih sistema sa modeliranjem i predviđanjem njihovih ponašanja pod neravnotežnim uslovima (RS-172015)
- Nanostrukturni funkcionalni i kompozitni materijali u katalitičkim i sorpcionim procesima (RS-45001)
DOI: 10.1111/adb.12409
ISSN: 1355-6215
PubMed: 27189379
WoS: 000413904600002
Scopus: 2-s2.0-84969922983
Institucija/grupa
IHTMTY - JOUR AU - Čupić, Željko AU - Stanojevic, Ana AU - Marković, Vladimir M. AU - Kolar-Anić, Ljiljana AU - Terenius, Lars AU - Vukojevic, Vladana PY - 2017 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/2087 AB - Stress and alcohol use are interrelatedstress contributes to the initiation and upholding of alcohol use and alcohol use alters the way we perceive and respond to stress. Intricate mechanisms through which ethanol alters the organism's response to stress remain elusive. We have developed a stoichiometric network model to succinctly describe neurochemical transformations underlying the stress response axis and use numerical simulations to model ethanol effects on complex daily changes of blood levels of cholesterol, 6 peptide and 8 steroid hormones. Modelling suggests that ethanol alters the dynamical regulation of hypothalamic-pituitary-adrenal (HPA) axis activity by affecting the amplitude of ultradian oscillations of HPA axis hormones, which defines the threshold with respect to which the response to stress is being set. These effects are complexlow/moderate acute ethanol challenge ( LT 8mM) may reduce, leave unaltered or increase the amplitude of ultradian cortisol (CORT) oscillations, giving rise to an intricate response at the organism level, offering also a potential explanation as to why apparently discordant results were observed in experimental studies. In contrast, high-dose acute ethanol challenge (> 8mM) increases instantaneous CORT levels and the amplitude of ultradian CORT oscillations in a dose-dependent manner, affecting the HPA axis activity also during the following day(s). Chronic exposure to ethanol qualitatively changes the HPA axis dynamics, whereas ethanol at intoxicating levels shuts down this dynamic regulation mechanism. Mathematical modelling gives a quantitative biology-based framework that can be used for predicting how the integral HPA axis response is perturbed by alcohol. PB - Wiley, Hoboken T2 - Addiction Biology T1 - The HPA axis and ethanol: a synthesis of mathematical modelling and experimental observations VL - 22 IS - 6 SP - 1486 EP - 1500 DO - 10.1111/adb.12409 ER -
@article{ author = "Čupić, Željko and Stanojevic, Ana and Marković, Vladimir M. and Kolar-Anić, Ljiljana and Terenius, Lars and Vukojevic, Vladana", year = "2017", abstract = "Stress and alcohol use are interrelatedstress contributes to the initiation and upholding of alcohol use and alcohol use alters the way we perceive and respond to stress. Intricate mechanisms through which ethanol alters the organism's response to stress remain elusive. We have developed a stoichiometric network model to succinctly describe neurochemical transformations underlying the stress response axis and use numerical simulations to model ethanol effects on complex daily changes of blood levels of cholesterol, 6 peptide and 8 steroid hormones. Modelling suggests that ethanol alters the dynamical regulation of hypothalamic-pituitary-adrenal (HPA) axis activity by affecting the amplitude of ultradian oscillations of HPA axis hormones, which defines the threshold with respect to which the response to stress is being set. These effects are complexlow/moderate acute ethanol challenge ( LT 8mM) may reduce, leave unaltered or increase the amplitude of ultradian cortisol (CORT) oscillations, giving rise to an intricate response at the organism level, offering also a potential explanation as to why apparently discordant results were observed in experimental studies. In contrast, high-dose acute ethanol challenge (> 8mM) increases instantaneous CORT levels and the amplitude of ultradian CORT oscillations in a dose-dependent manner, affecting the HPA axis activity also during the following day(s). Chronic exposure to ethanol qualitatively changes the HPA axis dynamics, whereas ethanol at intoxicating levels shuts down this dynamic regulation mechanism. Mathematical modelling gives a quantitative biology-based framework that can be used for predicting how the integral HPA axis response is perturbed by alcohol.", publisher = "Wiley, Hoboken", journal = "Addiction Biology", title = "The HPA axis and ethanol: a synthesis of mathematical modelling and experimental observations", volume = "22", number = "6", pages = "1486-1500", doi = "10.1111/adb.12409" }
Čupić, Ž., Stanojevic, A., Marković, V. M., Kolar-Anić, L., Terenius, L.,& Vukojevic, V.. (2017). The HPA axis and ethanol: a synthesis of mathematical modelling and experimental observations. in Addiction Biology Wiley, Hoboken., 22(6), 1486-1500. https://doi.org/10.1111/adb.12409
Čupić Ž, Stanojevic A, Marković VM, Kolar-Anić L, Terenius L, Vukojevic V. The HPA axis and ethanol: a synthesis of mathematical modelling and experimental observations. in Addiction Biology. 2017;22(6):1486-1500. doi:10.1111/adb.12409 .
Čupić, Željko, Stanojevic, Ana, Marković, Vladimir M., Kolar-Anić, Ljiljana, Terenius, Lars, Vukojevic, Vladana, "The HPA axis and ethanol: a synthesis of mathematical modelling and experimental observations" in Addiction Biology, 22, no. 6 (2017):1486-1500, https://doi.org/10.1111/adb.12409 . .