Synthesis and characterization of highly ordered self-assembled bioactive fulleropeptides
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2016
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Prikaz svih podataka o dokumentuApstrakt
A series of N-substituted fulleropyrrolidines containing peptide side chain was synthesized by the quantitative, TFA-mediated deprotection of the corresponding tert-butyl esters. The structures of all compounds were determined by comparative analysis of spectroscopic and spectrometric data. The electrochemical characterization, conducted by cyclic voltammetry at room temperature confirmed slightly attenuated reducibility in comparison to pristine C-60 and a weak long-range electron-accepting effect of the Gly(3)-fragment. The introduction of the peptide subunit led to improved solubility and enabled examination of the antioxidant properties in water environment. A notable radical scavenging activity of the fullerene subunit remained almost unchanged in all compounds. The investigation of the supramolecular self-assembling, performed by the scanning electron microscopy revealed an influence of the side chain, particularly the fraction of the hydrophobic residue, as well as the substrate... structure on the final morphology. Most of the compounds underwent highly ordered multi-stage hierarchical assembling to the attractive, flower-shaped supramolecular aggregates during both the precipitation and slow evaporation of the solvent.
Izvor:
Journal of Materials Science, 2016, 51, 2, 739-747Izdavač:
- Springer, New York
Finansiranje / projekti:
DOI: 10.1007/s10853-015-9396-z
ISSN: 0022-2461
WoS: 000365263900009
Scopus: 2-s2.0-84947495201
Institucija/grupa
IHTMTY - JOUR AU - Bjelaković, Mira AU - Kop, Tatjana AU - Maslak, Veselin AU - Milić, Dragana PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1983 AB - A series of N-substituted fulleropyrrolidines containing peptide side chain was synthesized by the quantitative, TFA-mediated deprotection of the corresponding tert-butyl esters. The structures of all compounds were determined by comparative analysis of spectroscopic and spectrometric data. The electrochemical characterization, conducted by cyclic voltammetry at room temperature confirmed slightly attenuated reducibility in comparison to pristine C-60 and a weak long-range electron-accepting effect of the Gly(3)-fragment. The introduction of the peptide subunit led to improved solubility and enabled examination of the antioxidant properties in water environment. A notable radical scavenging activity of the fullerene subunit remained almost unchanged in all compounds. The investigation of the supramolecular self-assembling, performed by the scanning electron microscopy revealed an influence of the side chain, particularly the fraction of the hydrophobic residue, as well as the substrate structure on the final morphology. Most of the compounds underwent highly ordered multi-stage hierarchical assembling to the attractive, flower-shaped supramolecular aggregates during both the precipitation and slow evaporation of the solvent. PB - Springer, New York T2 - Journal of Materials Science T1 - Synthesis and characterization of highly ordered self-assembled bioactive fulleropeptides VL - 51 IS - 2 SP - 739 EP - 747 DO - 10.1007/s10853-015-9396-z ER -
@article{ author = "Bjelaković, Mira and Kop, Tatjana and Maslak, Veselin and Milić, Dragana", year = "2016", abstract = "A series of N-substituted fulleropyrrolidines containing peptide side chain was synthesized by the quantitative, TFA-mediated deprotection of the corresponding tert-butyl esters. The structures of all compounds were determined by comparative analysis of spectroscopic and spectrometric data. The electrochemical characterization, conducted by cyclic voltammetry at room temperature confirmed slightly attenuated reducibility in comparison to pristine C-60 and a weak long-range electron-accepting effect of the Gly(3)-fragment. The introduction of the peptide subunit led to improved solubility and enabled examination of the antioxidant properties in water environment. A notable radical scavenging activity of the fullerene subunit remained almost unchanged in all compounds. The investigation of the supramolecular self-assembling, performed by the scanning electron microscopy revealed an influence of the side chain, particularly the fraction of the hydrophobic residue, as well as the substrate structure on the final morphology. Most of the compounds underwent highly ordered multi-stage hierarchical assembling to the attractive, flower-shaped supramolecular aggregates during both the precipitation and slow evaporation of the solvent.", publisher = "Springer, New York", journal = "Journal of Materials Science", title = "Synthesis and characterization of highly ordered self-assembled bioactive fulleropeptides", volume = "51", number = "2", pages = "739-747", doi = "10.1007/s10853-015-9396-z" }
Bjelaković, M., Kop, T., Maslak, V.,& Milić, D.. (2016). Synthesis and characterization of highly ordered self-assembled bioactive fulleropeptides. in Journal of Materials Science Springer, New York., 51(2), 739-747. https://doi.org/10.1007/s10853-015-9396-z
Bjelaković M, Kop T, Maslak V, Milić D. Synthesis and characterization of highly ordered self-assembled bioactive fulleropeptides. in Journal of Materials Science. 2016;51(2):739-747. doi:10.1007/s10853-015-9396-z .
Bjelaković, Mira, Kop, Tatjana, Maslak, Veselin, Milić, Dragana, "Synthesis and characterization of highly ordered self-assembled bioactive fulleropeptides" in Journal of Materials Science, 51, no. 2 (2016):739-747, https://doi.org/10.1007/s10853-015-9396-z . .