Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa
Аутори
Bukvicki, DankaCiric, Ana
Soković, Marina
Vannini, Lucia
Nissen, Lorenzo
Novaković, Miroslav
Vujisić, Ljubodrag V.
Asakawa, Yoshinori
Marin, Petar D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The chemical composition, antimicrobial and antiquorum sensing activity of the essential oil of Micromeria thymifolia (Scop.) Fritsch were investigated. Limonene, piperitone epoxide and piperitenone epoxide were found as the main constituents using a gas chromatography-mass spectrometry technique. In vitro antimicrobial activity of the oil was tested against six bacterial and seven fungal strains and high antimicrobial potential was noticed. Minimum inhibitory concentration varied from 0.031 mg/mL to 0.5 mg/mL for bacterial and 0.062 mg/mL to 0.5 mg/mL for fungal strains. The antiquorum properties of the essential oil were evaluated on Pseudomonas aeruginosa PAO1. The oil was tested at subMiC concentrations for anti-quorum sensing activity. The analyses on quorum-sensing functions have been carried out by evaluating twitching and swarming of bacterial cultures and the total amount of pyocyanin production produced by P. aeruginosa. This study showed that M thymifolia essential oil exhib...ited antiquorum sensing activity and may be used as an antipathogenic drug.
Кључне речи:
Micromeria thymifolia / Essential oil / Antimicrobial activity / Antiquorum effect / GC-MSИзвор:
Natural Product Communications, 2016, 11, 12, 1903-1906Издавач:
- Natural Products Inc, Westerville
Финансирање / пројекти:
- Микроморфолошка, фитохемијска и молекуларна истраживања биљака - систематски, еколошки и применљиви аспекти (RS-MESTD-Basic Research (BR or ON)-173029)
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
- Department of Agricultural and Food Sciences, University of Bologna, Italy
Институција/група
IHTMTY - JOUR AU - Bukvicki, Danka AU - Ciric, Ana AU - Soković, Marina AU - Vannini, Lucia AU - Nissen, Lorenzo AU - Novaković, Miroslav AU - Vujisić, Ljubodrag V. AU - Asakawa, Yoshinori AU - Marin, Petar D. PY - 2016 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1906 AB - The chemical composition, antimicrobial and antiquorum sensing activity of the essential oil of Micromeria thymifolia (Scop.) Fritsch were investigated. Limonene, piperitone epoxide and piperitenone epoxide were found as the main constituents using a gas chromatography-mass spectrometry technique. In vitro antimicrobial activity of the oil was tested against six bacterial and seven fungal strains and high antimicrobial potential was noticed. Minimum inhibitory concentration varied from 0.031 mg/mL to 0.5 mg/mL for bacterial and 0.062 mg/mL to 0.5 mg/mL for fungal strains. The antiquorum properties of the essential oil were evaluated on Pseudomonas aeruginosa PAO1. The oil was tested at subMiC concentrations for anti-quorum sensing activity. The analyses on quorum-sensing functions have been carried out by evaluating twitching and swarming of bacterial cultures and the total amount of pyocyanin production produced by P. aeruginosa. This study showed that M thymifolia essential oil exhibited antiquorum sensing activity and may be used as an antipathogenic drug. PB - Natural Products Inc, Westerville T2 - Natural Product Communications T1 - Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa VL - 11 IS - 12 SP - 1903 EP - 1906 UR - https://hdl.handle.net/21.15107/rcub_cherry_2374 ER -
@article{ author = "Bukvicki, Danka and Ciric, Ana and Soković, Marina and Vannini, Lucia and Nissen, Lorenzo and Novaković, Miroslav and Vujisić, Ljubodrag V. and Asakawa, Yoshinori and Marin, Petar D.", year = "2016", abstract = "The chemical composition, antimicrobial and antiquorum sensing activity of the essential oil of Micromeria thymifolia (Scop.) Fritsch were investigated. Limonene, piperitone epoxide and piperitenone epoxide were found as the main constituents using a gas chromatography-mass spectrometry technique. In vitro antimicrobial activity of the oil was tested against six bacterial and seven fungal strains and high antimicrobial potential was noticed. Minimum inhibitory concentration varied from 0.031 mg/mL to 0.5 mg/mL for bacterial and 0.062 mg/mL to 0.5 mg/mL for fungal strains. The antiquorum properties of the essential oil were evaluated on Pseudomonas aeruginosa PAO1. The oil was tested at subMiC concentrations for anti-quorum sensing activity. The analyses on quorum-sensing functions have been carried out by evaluating twitching and swarming of bacterial cultures and the total amount of pyocyanin production produced by P. aeruginosa. This study showed that M thymifolia essential oil exhibited antiquorum sensing activity and may be used as an antipathogenic drug.", publisher = "Natural Products Inc, Westerville", journal = "Natural Product Communications", title = "Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa", volume = "11", number = "12", pages = "1903-1906", url = "https://hdl.handle.net/21.15107/rcub_cherry_2374" }
Bukvicki, D., Ciric, A., Soković, M., Vannini, L., Nissen, L., Novaković, M., Vujisić, L. V., Asakawa, Y.,& Marin, P. D.. (2016). Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa. in Natural Product Communications Natural Products Inc, Westerville., 11(12), 1903-1906. https://hdl.handle.net/21.15107/rcub_cherry_2374
Bukvicki D, Ciric A, Soković M, Vannini L, Nissen L, Novaković M, Vujisić LV, Asakawa Y, Marin PD. Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa. in Natural Product Communications. 2016;11(12):1903-1906. https://hdl.handle.net/21.15107/rcub_cherry_2374 .
Bukvicki, Danka, Ciric, Ana, Soković, Marina, Vannini, Lucia, Nissen, Lorenzo, Novaković, Miroslav, Vujisić, Ljubodrag V., Asakawa, Yoshinori, Marin, Petar D., "Micromeria thymifolia Essential Oil Suppresses Quorum-sensing Signaling in Pseudomonas aeruginosa" in Natural Product Communications, 11, no. 12 (2016):1903-1906, https://hdl.handle.net/21.15107/rcub_cherry_2374 .