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Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models
dc.creator | Božić, Aleksandra R. | |
dc.creator | Marinković, Aleksandar D. | |
dc.creator | Bjelogrlić, Snežana K. | |
dc.creator | Todorović, Tamara | |
dc.creator | Cvijetić, Ilija | |
dc.creator | Novaković, Irena | |
dc.creator | Muller, Christian D. | |
dc.creator | Filipovic, Nenad R. | |
dc.date.accessioned | 2019-01-30T17:49:12Z | |
dc.date.available | 2019-01-30T17:49:12Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2046-2069 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/1895 | |
dc.description.abstract | A comparative study of antitumor activity of mono- and bis-quinoline based (thio) carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells (AsPC-1). Thiocarbohydrazones (TCHs) revealed superior pro-apoptotic activity over carbohydrazones (CHs) on both tested cell phenotypes, also displaying multi-target profile activities. Programmed cell death triggered by TCHs was partially caspase-dependent, mainly caspase-8 related. Activity against cancer stem cells (CSCs) was evaluated on 2D monolayers and 3D spheroidal models, where two out of three tested bis-TCHs successfully stimulated apoptosis accompanied by a reduction in size of treated spheres. Additionally, all bis-TCHs induced significant decrease in percentage of CD44-expressing AsPC-1 cells that indicate on their ability to induce reprogramming of CSC phenotype. Current results highly support further assessment of bis-TCHs in order to specify their specific targets in cancer cells and particularly in the CSCs subpopulation. | en |
dc.publisher | Royal Soc Chemistry, Cambridge | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS// | |
dc.relation | COST Action CM1106 StemChem - "Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells" | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | RSC Advances | |
dc.title | Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Филиповиц, Ненад Р.; Бјелогрлић, Снежана К.; Маринковиц, Aлександар; Новаковић, Ирена; Бозиц, Aлександра; Цвијетић, Илија Н.; Тодоровиц, Тамара Р.; Муллер, Цхристиан Д.; | |
dc.citation.volume | 6 | |
dc.citation.issue | 106 | |
dc.citation.spage | 104763 | |
dc.citation.epage | 104781 | |
dc.citation.other | 6(106): 104763-104781 | |
dc.citation.rank | M22 | |
dc.identifier.doi | 10.1039/c6ra23940d | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/8332/1893.pdf | |
dc.identifier.scopus | 2-s2.0-84994477669 | |
dc.identifier.wos | 000388111900107 | |
dc.type.version | publishedVersion |