Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay
Abstract
This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.
Keywords:
Antioxidants / CBMN assay / Heterocyclic compounds / Human lymphocytes DNASource:
Mini-Reviews in Medicinal Chemistry, 2013, 13, 3, 431-438Publisher:
- Bentham Science Publ Ltd, Sharjah
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
DOI: 10.2174/138955713804999856
ISSN: 1389-5575
PubMed: 23061623
WoS: 000317206800010
Scopus: 2-s2.0-84876829148
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Institution/Community
IHTMTY - JOUR AU - Gođevac, Dejan AU - Tešević, Vele AU - Vajs, Vlatka AU - Milosavljević, Slobodan AU - Stanković, Miroslava PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1353 AB - This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes. PB - Bentham Science Publ Ltd, Sharjah T2 - Mini-Reviews in Medicinal Chemistry T1 - Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay VL - 13 IS - 3 SP - 431 EP - 438 DO - 10.2174/138955713804999856 ER -
@article{ author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan and Stanković, Miroslava", year = "2013", abstract = "This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Mini-Reviews in Medicinal Chemistry", title = "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay", volume = "13", number = "3", pages = "431-438", doi = "10.2174/138955713804999856" }
Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S.,& Stanković, M.. (2013). Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini-Reviews in Medicinal Chemistry Bentham Science Publ Ltd, Sharjah., 13(3), 431-438. https://doi.org/10.2174/138955713804999856
Gođevac D, Tešević V, Vajs V, Milosavljević S, Stanković M. Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini-Reviews in Medicinal Chemistry. 2013;13(3):431-438. doi:10.2174/138955713804999856 .
Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan, Stanković, Miroslava, "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay" in Mini-Reviews in Medicinal Chemistry, 13, no. 3 (2013):431-438, https://doi.org/10.2174/138955713804999856 . .