Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity
Samo za registrovane korisnike
2013
Autori
Matić, Ivana Z.Juranić, Zorica
Savikin, Katarina
Zdunić, Gordana
Nadvinski, Neva
Gođevac, Dejan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the act...ion to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated.
Ključne reči:
antioxidant activity / chamomile tea / chemical profile / cytotoxic effect / marigold teaIzvor:
Phytotherapy Research, 2013, 27, 6, 852-858Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Modifikatori biološkog odgovora u fiziološkim i patološkim stanjima (RS-175011)
- Tradicionalni i novi proizvodi od plodova gajenih i samoniklih vrsta voćaka i vinove loze i nus-produkata u preradi, sa posebnim osvrtom na autohtone sorte: hemijska karakterizacija i biološki profil (RS-46013)
DOI: 10.1002/ptr.4807
ISSN: 0951-418X
PubMed: 22899374
WoS: 000320114500009
Scopus: 2-s2.0-84878827887
Institucija/grupa
IHTMTY - JOUR AU - Matić, Ivana Z. AU - Juranić, Zorica AU - Savikin, Katarina AU - Zdunić, Gordana AU - Nadvinski, Neva AU - Gođevac, Dejan PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1338 AB - With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the action to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated. PB - Wiley, Hoboken T2 - Phytotherapy Research T1 - Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity VL - 27 IS - 6 SP - 852 EP - 858 DO - 10.1002/ptr.4807 ER -
@article{ author = "Matić, Ivana Z. and Juranić, Zorica and Savikin, Katarina and Zdunić, Gordana and Nadvinski, Neva and Gođevac, Dejan", year = "2013", abstract = "With the aim to evaluate the selectivity in the antitumor action, the cytotoxic activity of chamomile and marigold tea was tested against various malignant cell lines and against healthy immunocompetent peripheral blood mononuclear cells (PBMC). Chemical profiles of chamomile and marigold infusions and decoctions were analyzed by liquid chromatography/mass spectrometry; their total phenolic content and radical scavenging activity were determined, too. Results from present research demonstrate that chamomile and marigold tea exert selective dose-dependent cytotoxic action against target cancer cells. It is noteworthy that cytotoxicity of tea prepared from Calendula officinalis is remarkably higher in comparison to that from Matricaria recutita tea. The cytotoxic effect of chamomile tea is very weak to healthy PBMC, while the effect of marigold tea on PBMC is more pronounced. Marigold tea exerts highly selective antitumor effect especially to melanoma Fem-x cells in comparison to the action to normal healthy PBMC. Chemical analyses show that dominant phenolic compounds in examined infusions and decoctions are flavonoid glycosides and hydroxycinnamic acid derivatives. There are no considerable differences in total phenolic content and antioxidant activity between examined infusions. Antitumor potential of chamomile and marigold tea should be further investigated.", publisher = "Wiley, Hoboken", journal = "Phytotherapy Research", title = "Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity", volume = "27", number = "6", pages = "852-858", doi = "10.1002/ptr.4807" }
Matić, I. Z., Juranić, Z., Savikin, K., Zdunić, G., Nadvinski, N.,& Gođevac, D.. (2013). Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity. in Phytotherapy Research Wiley, Hoboken., 27(6), 852-858. https://doi.org/10.1002/ptr.4807
Matić IZ, Juranić Z, Savikin K, Zdunić G, Nadvinski N, Gođevac D. Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity. in Phytotherapy Research. 2013;27(6):852-858. doi:10.1002/ptr.4807 .
Matić, Ivana Z., Juranić, Zorica, Savikin, Katarina, Zdunić, Gordana, Nadvinski, Neva, Gođevac, Dejan, "Chamomile and Marigold Tea: Chemical Characterization and Evaluation of Anticancer Activity" in Phytotherapy Research, 27, no. 6 (2013):852-858, https://doi.org/10.1002/ptr.4807 . .