Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates
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2013
Authors
Stefanovic, JovanaJakovljević, Dragica
Gojgić-Cvijović, Gordana
Lazić, Miodrag L.
Vrvić, Miroslav
Article (Published version)
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Show full item recordAbstract
Nystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stabil...ity than pure drug.
Keywords:
nystatin / polysaccharide / coupling / solubility / antifungal activitySource:
Journal of Applied Polymer Science, 2013, 127, 6, 4736-4743Publisher:
- Wiley-Blackwell, Malden
Funding / projects:
- Simultaneous Bioremediation and Soilification of Degraded Areas to Preserve Natural Resources of Biologically Active Substances, and Development and Production of Biomaterials and Dietetic Products (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
DOI: 10.1002/app.38084
ISSN: 0021-8995
WoS: 000312940400064
Scopus: 2-s2.0-84871615987
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IHTMTY - JOUR AU - Stefanovic, Jovana AU - Jakovljević, Dragica AU - Gojgić-Cvijović, Gordana AU - Lazić, Miodrag L. AU - Vrvić, Miroslav PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1311 AB - Nystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stability than pure drug. PB - Wiley-Blackwell, Malden T2 - Journal of Applied Polymer Science T1 - Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates VL - 127 IS - 6 SP - 4736 EP - 4743 DO - 10.1002/app.38084 ER -
@article{ author = "Stefanovic, Jovana and Jakovljević, Dragica and Gojgić-Cvijović, Gordana and Lazić, Miodrag L. and Vrvić, Miroslav", year = "2013", abstract = "Nystatin, a polyene tetraene antibiotic widely used in the treatment of mycoses, was coupled with oxidized polysaccharide gum Arabic, by forming Schiff base structures between amine groups of antibiotics and aldehyde groups of modified carbohydrate. Imine conjugates synthesized in this way were reduced with sodium borohydride to secondary amines. Two imine and two amine conjugates were obtained with different nystatin content. The conjugates were characterized by UVVis, FTIR, 1H NMR spectroscopy, and thermogravimetric analysis. Solubility in water, unlike nystatin, and significant activity against Candida albicans and Aspergillus niger with minimum inhibitory concentrations in range of 3.1256.25 mu g mL-1 and 6.2525 mu g mL-1, respectively, indicate that the chemical integrity and the biological function of these compounds were retained. A comparison of stability of the conjugates in the dry form, solution and under different pH values showed that the conjugates exhibited better stability than pure drug.", publisher = "Wiley-Blackwell, Malden", journal = "Journal of Applied Polymer Science", title = "Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates", volume = "127", number = "6", pages = "4736-4743", doi = "10.1002/app.38084" }
Stefanovic, J., Jakovljević, D., Gojgić-Cvijović, G., Lazić, M. L.,& Vrvić, M.. (2013). Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates. in Journal of Applied Polymer Science Wiley-Blackwell, Malden., 127(6), 4736-4743. https://doi.org/10.1002/app.38084
Stefanovic J, Jakovljević D, Gojgić-Cvijović G, Lazić ML, Vrvić M. Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates. in Journal of Applied Polymer Science. 2013;127(6):4736-4743. doi:10.1002/app.38084 .
Stefanovic, Jovana, Jakovljević, Dragica, Gojgić-Cvijović, Gordana, Lazić, Miodrag L., Vrvić, Miroslav, "Synthesis, characterization, and antifungal activity of nystatingum arabic conjugates" in Journal of Applied Polymer Science, 127, no. 6 (2013):4736-4743, https://doi.org/10.1002/app.38084 . .