Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis
Samo za registrovane korisnike
2013
Autori
Matić, Ivana Z.Aljančić, Ivana
Vajs, Vlatka
Jadranin, Milka
Gligorijević, Nevenka
Milosavljević, Slobodan
Juranić, Zorica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Helichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated... with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties.
Ključne reči:
Helichrysum zivojinii / MDA-MB-231 / EA.hy926 / cytotoxic action / Invasiveness / Angiogenesis in vitroIzvor:
Natural Product Communications, 2013, 8, 9, 1291-1296Izdavač:
- Natural Products Inc, Westerville
Finansiranje / projekti:
- Modifikatori biološkog odgovora u fiziološkim i patološkim stanjima (RS-MESTD-Basic Research (BR or ON)-175011)
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
Institucija/grupa
IHTMTY - JOUR AU - Matić, Ivana Z. AU - Aljančić, Ivana AU - Vajs, Vlatka AU - Jadranin, Milka AU - Gligorijević, Nevenka AU - Milosavljević, Slobodan AU - Juranić, Zorica PY - 2013 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1264 AB - Helichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties. PB - Natural Products Inc, Westerville T2 - Natural Product Communications T1 - Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis VL - 8 IS - 9 SP - 1291 EP - 1296 UR - https://hdl.handle.net/21.15107/rcub_cherry_1435 ER -
@article{ author = "Matić, Ivana Z. and Aljančić, Ivana and Vajs, Vlatka and Jadranin, Milka and Gligorijević, Nevenka and Milosavljević, Slobodan and Juranić, Zorica", year = "2013", abstract = "Helichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties.", publisher = "Natural Products Inc, Westerville", journal = "Natural Product Communications", title = "Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis", volume = "8", number = "9", pages = "1291-1296", url = "https://hdl.handle.net/21.15107/rcub_cherry_1435" }
Matić, I. Z., Aljančić, I., Vajs, V., Jadranin, M., Gligorijević, N., Milosavljević, S.,& Juranić, Z.. (2013). Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis. in Natural Product Communications Natural Products Inc, Westerville., 8(9), 1291-1296. https://hdl.handle.net/21.15107/rcub_cherry_1435
Matić IZ, Aljančić I, Vajs V, Jadranin M, Gligorijević N, Milosavljević S, Juranić Z. Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis. in Natural Product Communications. 2013;8(9):1291-1296. https://hdl.handle.net/21.15107/rcub_cherry_1435 .
Matić, Ivana Z., Aljančić, Ivana, Vajs, Vlatka, Jadranin, Milka, Gligorijević, Nevenka, Milosavljević, Slobodan, Juranić, Zorica, "Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis" in Natural Product Communications, 8, no. 9 (2013):1291-1296, https://hdl.handle.net/21.15107/rcub_cherry_1435 .