Characterization and behavior of anesthetic bioactive textile complex in vitro condition
Само за регистроване кориснике
2012
Аутори
Simovic, LjSkundric, P.
Baralic, A. Medovic
Pajic-Lijakovic, I.
Milutinović Nikolić, Aleksandra
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, ...membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.
Кључне речи:
mathematical model / lidocaine / nonwoven / chitosan / controlled releaseИзвор:
Journal of Biomedical Materials Research Part A, 2012, 1, 1-6Издавач:
- Wiley-Blackwell, Malden
Финансирање / пројекти:
- Средњовековне српске земље (XIII-XV век): политички, привредни, друштвени и правни процеси (RS-MESTD-Basic Research (BR or ON)-177029)
DOI: 10.1002/jbm.a.33234
ISSN: 1549-3296
PubMed: 21954107
WoS: 000297740800001
Scopus: 2-s2.0-81855182166
Институција/група
IHTMTY - JOUR AU - Simovic, Lj AU - Skundric, P. AU - Baralic, A. Medovic AU - Pajic-Lijakovic, I. AU - Milutinović Nikolić, Aleksandra PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1053 AB - In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model. PB - Wiley-Blackwell, Malden T2 - Journal of Biomedical Materials Research Part A T1 - Characterization and behavior of anesthetic bioactive textile complex in vitro condition IS - 1 SP - 1 EP - 6 DO - 10.1002/jbm.a.33234 ER -
@article{ author = "Simovic, Lj and Skundric, P. and Baralic, A. Medovic and Pajic-Lijakovic, I. and Milutinović Nikolić, Aleksandra", year = "2012", abstract = "In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that more than 97% of pores in untreated nonwoven sample were larger than 15 mu m. Anesthetic treatment of nonwoven reduced total pore volume of ultramacropores and macropores, while total pore volume of mesopores slightly increased. Lidocaine hydrochloride release from the anesthetic/chitosan hydrogel/nonwoven complex was measured in vitro by Franz diffusion cell technique. Mathematical model was developed to estimate the release of the lidocaine from obtained bioactive textile material. The diffusive transport of lidocaine hydrochloride through three connected layers, i.e., polymer hydrogel, membrane, and solution is modeled based on Fick's second law. Taking all the relevant conditions, regarding this experiment, into consideration, the coefficient of lidocaine diffusion through the polymer hydrogel, as well as the concentration ratio parameter were determined by the mathematical model.", publisher = "Wiley-Blackwell, Malden", journal = "Journal of Biomedical Materials Research Part A", title = "Characterization and behavior of anesthetic bioactive textile complex in vitro condition", number = "1", pages = "1-6", doi = "10.1002/jbm.a.33234" }
Simovic, L., Skundric, P., Baralic, A. M., Pajic-Lijakovic, I.,& Milutinović Nikolić, A.. (2012). Characterization and behavior of anesthetic bioactive textile complex in vitro condition. in Journal of Biomedical Materials Research Part A Wiley-Blackwell, Malden.(1), 1-6. https://doi.org/10.1002/jbm.a.33234
Simovic L, Skundric P, Baralic AM, Pajic-Lijakovic I, Milutinović Nikolić A. Characterization and behavior of anesthetic bioactive textile complex in vitro condition. in Journal of Biomedical Materials Research Part A. 2012;(1):1-6. doi:10.1002/jbm.a.33234 .
Simovic, Lj, Skundric, P., Baralic, A. Medovic, Pajic-Lijakovic, I., Milutinović Nikolić, Aleksandra, "Characterization and behavior of anesthetic bioactive textile complex in vitro condition" in Journal of Biomedical Materials Research Part A, no. 1 (2012):1-6, https://doi.org/10.1002/jbm.a.33234 . .