Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors
Apstrakt
We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement.
Ključne reči:
Biosensor / competitive adsorption / mass transfer / adsorbed mass fluctuationsIzvor:
26th European Conference on Solid-State Transducers, Eurosensor 2012, 2012, 47, 957-960Izdavač:
- Elsevier
Finansiranje / projekti:
- Mikro, nano-sistemi i senzori za primenu u elektroprivredi, procesnoj industriji i zaštiti životne sredine (RS-MESTD-Technological Development (TD or TR)-32008)
DOI: 10.1016/j.proeng.2012.09.305
ISSN: 1877-7058
WoS: 000312953300236
Scopus: 2-s2.0-84891677032
Institucija/grupa
IHTMTY - CONF AU - Frantlović, Miloš AU - Jokić, Ivana AU - Đurić, Zoran G. AU - Radulović, Katarina PY - 2012 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/1051 AB - We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement. PB - Elsevier C3 - 26th European Conference on Solid-State Transducers, Eurosensor 2012 T1 - Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors VL - 47 SP - 957 EP - 960 DO - 10.1016/j.proeng.2012.09.305 ER -
@conference{ author = "Frantlović, Miloš and Jokić, Ivana and Đurić, Zoran G. and Radulović, Katarina", year = "2012", abstract = "We analyze the fluctuations of the equilibrium adsorbed mass in affinity-based biosensors, caused by both the random nature of adsorption-desorption and mass transfer processes of two molecular species (the target and the competitor molecules) which bind to the probe molecules. The analytical expression for the fluctuations spectral density is derived. The calculations show the significant influence of both the competitive adsorption and the mass transfer on the fluctuations spectrum. The theory provides a more realistic estimation of limiting performance of biosensors, and is useful for their improvement.", publisher = "Elsevier", journal = "26th European Conference on Solid-State Transducers, Eurosensor 2012", title = "Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors", volume = "47", pages = "957-960", doi = "10.1016/j.proeng.2012.09.305" }
Frantlović, M., Jokić, I., Đurić, Z. G.,& Radulović, K.. (2012). Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors. in 26th European Conference on Solid-State Transducers, Eurosensor 2012 Elsevier., 47, 957-960. https://doi.org/10.1016/j.proeng.2012.09.305
Frantlović M, Jokić I, Đurić ZG, Radulović K. Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors. in 26th European Conference on Solid-State Transducers, Eurosensor 2012. 2012;47:957-960. doi:10.1016/j.proeng.2012.09.305 .
Frantlović, Miloš, Jokić, Ivana, Đurić, Zoran G., Radulović, Katarina, "Analysis of the Influence of Competitive Adsorption and Mass Transfer on Adsorbed Mass Fluctuations in Affinity-Based Biosensors" in 26th European Conference on Solid-State Transducers, Eurosensor 2012, 47 (2012):957-960, https://doi.org/10.1016/j.proeng.2012.09.305 . .