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dc.creatorIgnjatović, Đurđica S.
dc.creatorMilutinovic, Danijela Vojnovic
dc.creatorNikolić-Kokić, Aleksandra
dc.creatorSlavic, Marija
dc.creatorAndrić, Deana
dc.creatorTomić, Mirko
dc.creatorKostić Rajačić, Slađana
dc.date.accessioned2019-01-30T17:29:21Z
dc.date.available2019-01-30T17:29:21Z
dc.date.issued2012
dc.identifier.issn0014-2999
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/955
dc.description.abstractA group of sixteen arylpiperazines had been previously synthesized and evaluated for atypical antipsychotic activity. Here we examined these compounds for their neuroprotective capacity. The affinity and agonist/antagonist action of the arylpiperazines at dopamine hD(2S) receptors were determined in vitro on membranes from stably transfected CHO-hD(2S) cell line. The assays for cell viability and antioxidative capacity (total glutathione and total superoxide dismutase activity), amount of nitric oxide and superoxide radicals, as well as influence on prosurvival pathways (Akt and ERK), were performed on the human neuroblastoma cell line SH-SY5Y. Cell death was induced by oxidative or nitrosative stress, or by growing cells in the medium deprived of serum. Only four of the arylpiperazines exhibited notable neuroprotection against cell death induced by sodium nitroprusside. Two of these arylpiperazines induced elevations of pAkt, while two other compounds reduced the levels of pErk, whereas these actions are considered to support the cell survival. The benzimidazole heteroaryl-group, that mimics catechol moiety of the dopamine molecule, might be the prerequisite structure for the neuroprotective action of these ligands. It is postulated that neuroprotection was acquired also by elevation of endogenous glutathione or total superoxide dismutase activity.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmacology
dc.subjectArylpiperazinesen
dc.subjectDopamine agonisten
dc.subjectNeuroprotectionen
dc.subjectParkinson's diseaseen
dc.subjectOxidative stressen
dc.titleThe mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprussideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТомиц, Мирко; Игњатовић, Ђурђица С.; Костић Рајачић, Слађана; Николиц-Кокиц, Aлександра; Славиц, Марија; Милутиновиц, Данијела Војновиц; Aндриц, Деана;
dc.citation.volume683
dc.citation.issue1-3
dc.citation.spage93
dc.citation.epage100
dc.citation.other683(1-3): 93-100
dc.citation.rankM22
dc.identifier.pmid22449382
dc.identifier.doi10.1016/j.ejphar.2012.03.011
dc.identifier.rcubConv_2789
dc.identifier.scopus2-s2.0-84860456786
dc.identifier.wos000303436200012
dc.type.versionpublishedVersion


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