Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations
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Приказ свих података о документуАпстракт
For a long time, Reversed-Phase Liquid Chromatography (RPLC) was the most dominant
technique for the analysis of pharmaceutical compounds, but with poor efficiency in the separation of
small polar molecules. From the efforts to solve the problem of insufficient retention of these molecules,
during the last decades, a mode of liquid chromatography named Hydrophilic Interaction Liquid
Chromatography (HILIC) has experienced vast expansion. It is based on the use of a highly hydrophilic
stationary phase along with an aqueous mobile phase with high organic modifier content. In
this review, the characteristics of stationary and mobile phases used in HILIC are described, and corresponding
separation mechanisms are discussed. An overview of recently published papers dealing
with the application of HILIC in analyzing pharmaceuticals in biological and non-biological samples
is provided. Besides, the application of HILIC systems in the determination of the physicochemical
properties of ...compounds is described.
Кључне речи:
Hydrophilic interaction liquid chromatography / pharmaceutical application / polar compounds / polar stationary phase / hydrophilic partitioning / hydrogen bonding / electrostatic interactionsИзвор:
Current Analytical Chemistry, 2024, 20, 5, 295-317Издавач:
- Bentham Science Publishers
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
Институција/група
IHTMTY - JOUR AU - Radoičić, Aleksandra AU - Šegan, Sandra AU - Dramićanin, Aleksandra AU - Milojković-Opsenica, Dušanka PY - 2024 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7609 AB - For a long time, Reversed-Phase Liquid Chromatography (RPLC) was the most dominant technique for the analysis of pharmaceutical compounds, but with poor efficiency in the separation of small polar molecules. From the efforts to solve the problem of insufficient retention of these molecules, during the last decades, a mode of liquid chromatography named Hydrophilic Interaction Liquid Chromatography (HILIC) has experienced vast expansion. It is based on the use of a highly hydrophilic stationary phase along with an aqueous mobile phase with high organic modifier content. In this review, the characteristics of stationary and mobile phases used in HILIC are described, and corresponding separation mechanisms are discussed. An overview of recently published papers dealing with the application of HILIC in analyzing pharmaceuticals in biological and non-biological samples is provided. Besides, the application of HILIC systems in the determination of the physicochemical properties of compounds is described. PB - Bentham Science Publishers T2 - Current Analytical Chemistry T1 - Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations VL - 20 IS - 5 SP - 295 EP - 317 DO - 10.2174/0115734110290557240305045032 ER -
@article{ author = "Radoičić, Aleksandra and Šegan, Sandra and Dramićanin, Aleksandra and Milojković-Opsenica, Dušanka", year = "2024", abstract = "For a long time, Reversed-Phase Liquid Chromatography (RPLC) was the most dominant technique for the analysis of pharmaceutical compounds, but with poor efficiency in the separation of small polar molecules. From the efforts to solve the problem of insufficient retention of these molecules, during the last decades, a mode of liquid chromatography named Hydrophilic Interaction Liquid Chromatography (HILIC) has experienced vast expansion. It is based on the use of a highly hydrophilic stationary phase along with an aqueous mobile phase with high organic modifier content. In this review, the characteristics of stationary and mobile phases used in HILIC are described, and corresponding separation mechanisms are discussed. An overview of recently published papers dealing with the application of HILIC in analyzing pharmaceuticals in biological and non-biological samples is provided. Besides, the application of HILIC systems in the determination of the physicochemical properties of compounds is described.", publisher = "Bentham Science Publishers", journal = "Current Analytical Chemistry", title = "Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations", volume = "20", number = "5", pages = "295-317", doi = "10.2174/0115734110290557240305045032" }
Radoičić, A., Šegan, S., Dramićanin, A.,& Milojković-Opsenica, D.. (2024). Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations. in Current Analytical Chemistry Bentham Science Publishers., 20(5), 295-317. https://doi.org/10.2174/0115734110290557240305045032
Radoičić A, Šegan S, Dramićanin A, Milojković-Opsenica D. Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations. in Current Analytical Chemistry. 2024;20(5):295-317. doi:10.2174/0115734110290557240305045032 .
Radoičić, Aleksandra, Šegan, Sandra, Dramićanin, Aleksandra, Milojković-Opsenica, Dušanka, "Hydrophilic Interaction Liquid Chromatography for the Analysis of Pharmaceutical Formulations" in Current Analytical Chemistry, 20, no. 5 (2024):295-317, https://doi.org/10.2174/0115734110290557240305045032 . .