Synthesis and antitumour activity of two dephenilated (-)-goniofufurone analogues

Abstract

(-)-Goniofufurone (1) is a synthetic styryl lactone that exhibits significant antitumor activity. In the search for new and more potent antitumor agents the synthesis of lactones 5 and 6 was planned from D-glucose. Compounds 5 and 6 are designed as dephenylated analogues of 1 (Figure 1). The results of the evaluation of antiproliferative activity of 5 and 6 against a number of human tumor cell lines, as well as the structure-activity relationship (SAR), will be presented and discussed in details.