Synthesis and antitumour activity of two dephenilated (-)-goniofufurone analogues
2019
Autori
Srećo Zelenović, BojanaKekezović, Slađana
Kojić, Vesna V.
Benedeković, Goran
Jadranin, Milka
Popsavin, Mirjana
Popsavin, Velimir
Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
(-)-Goniofufurone (1) is a synthetic styryl lactone that exhibits significant antitumor activity. In the search for new and more potent antitumor agents the synthesis of lactones 5 and 6 was planned from D-glucose. Compounds 5 and 6 are designed as dephenylated analogues of 1 (Figure 1). The results of the evaluation of antiproliferative activity of 5 and 6 against a number of human tumor cell lines, as well as the structure-activity relationship (SAR), will be presented and discussed in details.
Ključne reči:
(-)-Goniofufurone / synthesis / D-glucose / antiproliferative activity / structure-activity relationshipIzvor:
Book of Abstracts - 9th International Conferences of the Chemical Societies of the South-Eastern European Countries, ICOSECS9, "Chemistry a Nature Challenger", Targoviste, Romania, 2019, S3_P16-S3_P16Izdavač:
- Valahia University of Targoviste
- University Politehnica of Bucharest
Finansiranje / projekti:
- Sinteza i biološka ispitivanja novih mimetika ili derivata odabranih citotoksičnih laktona, antitumorskog agensa tiazofurina i prirodnih naftnih kiselina (RS-MESTD-Basic Research (BR or ON)-172006)
Institucija/grupa
IHTMTY - CONF AU - Srećo Zelenović, Bojana AU - Kekezović, Slađana AU - Kojić, Vesna V. AU - Benedeković, Goran AU - Jadranin, Milka AU - Popsavin, Mirjana AU - Popsavin, Velimir PY - 2019 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7275 AB - (-)-Goniofufurone (1) is a synthetic styryl lactone that exhibits significant antitumor activity. In the search for new and more potent antitumor agents the synthesis of lactones 5 and 6 was planned from D-glucose. Compounds 5 and 6 are designed as dephenylated analogues of 1 (Figure 1). The results of the evaluation of antiproliferative activity of 5 and 6 against a number of human tumor cell lines, as well as the structure-activity relationship (SAR), will be presented and discussed in details. PB - Valahia University of Targoviste PB - University Politehnica of Bucharest C3 - Book of Abstracts - 9th International Conferences of the Chemical Societies of the South-Eastern European Countries, ICOSECS9, "Chemistry a Nature Challenger", Targoviste, Romania T1 - Synthesis and antitumour activity of two dephenilated (-)-goniofufurone analogues SP - S3_P16 EP - S3_P16 UR - https://hdl.handle.net/21.15107/rcub_cer_7275 ER -
@conference{ author = "Srećo Zelenović, Bojana and Kekezović, Slađana and Kojić, Vesna V. and Benedeković, Goran and Jadranin, Milka and Popsavin, Mirjana and Popsavin, Velimir", year = "2019", abstract = "(-)-Goniofufurone (1) is a synthetic styryl lactone that exhibits significant antitumor activity. In the search for new and more potent antitumor agents the synthesis of lactones 5 and 6 was planned from D-glucose. Compounds 5 and 6 are designed as dephenylated analogues of 1 (Figure 1). The results of the evaluation of antiproliferative activity of 5 and 6 against a number of human tumor cell lines, as well as the structure-activity relationship (SAR), will be presented and discussed in details.", publisher = "Valahia University of Targoviste, University Politehnica of Bucharest", journal = "Book of Abstracts - 9th International Conferences of the Chemical Societies of the South-Eastern European Countries, ICOSECS9, "Chemistry a Nature Challenger", Targoviste, Romania", title = "Synthesis and antitumour activity of two dephenilated (-)-goniofufurone analogues", pages = "S3_P16-S3_P16", url = "https://hdl.handle.net/21.15107/rcub_cer_7275" }
Srećo Zelenović, B., Kekezović, S., Kojić, V. V., Benedeković, G., Jadranin, M., Popsavin, M.,& Popsavin, V.. (2019). Synthesis and antitumour activity of two dephenilated (-)-goniofufurone analogues. in Book of Abstracts - 9th International Conferences of the Chemical Societies of the South-Eastern European Countries, ICOSECS9, "Chemistry a Nature Challenger", Targoviste, Romania Valahia University of Targoviste., S3_P16-S3_P16. https://hdl.handle.net/21.15107/rcub_cer_7275
Srećo Zelenović B, Kekezović S, Kojić VV, Benedeković G, Jadranin M, Popsavin M, Popsavin V. Synthesis and antitumour activity of two dephenilated (-)-goniofufurone analogues. in Book of Abstracts - 9th International Conferences of the Chemical Societies of the South-Eastern European Countries, ICOSECS9, "Chemistry a Nature Challenger", Targoviste, Romania. 2019;:S3_P16-S3_P16. https://hdl.handle.net/21.15107/rcub_cer_7275 .
Srećo Zelenović, Bojana, Kekezović, Slađana, Kojić, Vesna V., Benedeković, Goran, Jadranin, Milka, Popsavin, Mirjana, Popsavin, Velimir, "Synthesis and antitumour activity of two dephenilated (-)-goniofufurone analogues" in Book of Abstracts - 9th International Conferences of the Chemical Societies of the South-Eastern European Countries, ICOSECS9, "Chemistry a Nature Challenger", Targoviste, Romania (2019):S3_P16-S3_P16, https://hdl.handle.net/21.15107/rcub_cer_7275 .