Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release
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Приказ свих података о документуАпстракт
Drug delivery system is an amazing tool which is widely used for drugprotection and its controlled release in order to enhance drug bioavailability,reduce side effects and therefore to improve overall therapy. Hydrogels havebeen attracted great attention as drug carriers due to their great physicochemicalproperties, similarity to the living tissues and biocompatibility. One group ofpH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). Thesenon-toxic hydrogels are used as drug delivery system because they swell asa response to the change in pH of external environment and drug is beingreleased during the process. In present study, in order to improve the control ofdrug release rate, caffeine was encapsulated in liposomes which were furtherembedded into PMC hydrogel (PMCL). It was investigated how the change inneutralization degree of methacrylic acid affect the swelling degree of PMCLhydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 Mhydrochloride aci...d (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), asa simulation of pH environment in human stomach and intestines, respectively.Obtained results show that PMCL hydrogels have great potential for controlledrelease of poorly water-soluble drugs in human intestines.
Кључне речи:
hydrogels / casein / liposomes / neutralization degree / release kineticsИзвор:
Journal of Chemists, Technologists and Environmentalists, 2022, 3, 1, 1-5Издавач:
- The Faculty of Technology, University of Banja Luka
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200287 (Иновациони центар Технолошко-металуршког факултета у Београду доо) (RS-MESTD-inst-2020-200287)
Институција/група
IHTMTY - JOUR AU - Pantić, Olga AU - Pjanović, Rada AU - Panić, Vesna AU - Savić, Sanja AU - Spasojević, Pavle AU - Marković, Maja D. PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6955 AB - Drug delivery system is an amazing tool which is widely used for drugprotection and its controlled release in order to enhance drug bioavailability,reduce side effects and therefore to improve overall therapy. Hydrogels havebeen attracted great attention as drug carriers due to their great physicochemicalproperties, similarity to the living tissues and biocompatibility. One group ofpH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). Thesenon-toxic hydrogels are used as drug delivery system because they swell asa response to the change in pH of external environment and drug is beingreleased during the process. In present study, in order to improve the control ofdrug release rate, caffeine was encapsulated in liposomes which were furtherembedded into PMC hydrogel (PMCL). It was investigated how the change inneutralization degree of methacrylic acid affect the swelling degree of PMCLhydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 Mhydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), asa simulation of pH environment in human stomach and intestines, respectively.Obtained results show that PMCL hydrogels have great potential for controlledrelease of poorly water-soluble drugs in human intestines. PB - The Faculty of Technology, University of Banja Luka T2 - Journal of Chemists, Technologists and Environmentalists T1 - Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release VL - 3 IS - 1 SP - 1 EP - 5 DO - 10.7251/JCTE2203001P ER -
@article{ author = "Pantić, Olga and Pjanović, Rada and Panić, Vesna and Savić, Sanja and Spasojević, Pavle and Marković, Maja D.", year = "2022", abstract = "Drug delivery system is an amazing tool which is widely used for drugprotection and its controlled release in order to enhance drug bioavailability,reduce side effects and therefore to improve overall therapy. Hydrogels havebeen attracted great attention as drug carriers due to their great physicochemicalproperties, similarity to the living tissues and biocompatibility. One group ofpH sensitive hydrogels are based on poly(methacrylic acid) (PMAA). Thesenon-toxic hydrogels are used as drug delivery system because they swell asa response to the change in pH of external environment and drug is beingreleased during the process. In present study, in order to improve the control ofdrug release rate, caffeine was encapsulated in liposomes which were furtherembedded into PMC hydrogel (PMCL). It was investigated how the change inneutralization degree of methacrylic acid affect the swelling degree of PMCLhydrogels and caffeine release in two environments at 37 °C for 24 h: 0.1 Mhydrochloride acid (pH 1) and phosphate buffer with pH value of 6.8 (pH 6.8), asa simulation of pH environment in human stomach and intestines, respectively.Obtained results show that PMCL hydrogels have great potential for controlledrelease of poorly water-soluble drugs in human intestines.", publisher = "The Faculty of Technology, University of Banja Luka", journal = "Journal of Chemists, Technologists and Environmentalists", title = "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release", volume = "3", number = "1", pages = "1-5", doi = "10.7251/JCTE2203001P" }
Pantić, O., Pjanović, R., Panić, V., Savić, S., Spasojević, P.,& Marković, M. D.. (2022). Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists The Faculty of Technology, University of Banja Luka., 3(1), 1-5. https://doi.org/10.7251/JCTE2203001P
Pantić O, Pjanović R, Panić V, Savić S, Spasojević P, Marković MD. Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release. in Journal of Chemists, Technologists and Environmentalists. 2022;3(1):1-5. doi:10.7251/JCTE2203001P .
Pantić, Olga, Pjanović, Rada, Panić, Vesna, Savić, Sanja, Spasojević, Pavle, Marković, Maja D., "Effect of neutralization degree of methacrylic acid on hydrogel swelling and drug release" in Journal of Chemists, Technologists and Environmentalists, 3, no. 1 (2022):1-5, https://doi.org/10.7251/JCTE2203001P . .