Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients
Аутори
Simić, KatarinaMiladinović, Zoran
Todorović, Nina
Trifunović, Snežana
Avramović, Nataša
Gavrilović, Aleksandra
Jovanović, Silvana
Gođevac, Dejan
Vujisić, Ljubodrag
Tešević, Vele
Tasic, Ljubica
Mandić, Boris
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden. The complexity of this disease, including diverse genetic, environmental, and biochemical factors, and diagnoses based on the subjective recognition of symptoms without any clinical test of biomarker identification create significant difficulties in understanding and diagnosing BD. A 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD (33) and healthy controls (39) was explored, providing the identification of 22 metabolites for this disease. A biomarker set including threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose was established for the first time in BD serum samples by an NMR-based metabolomics study. Six identified metabolites (3-hydroxybutyric acid, arginine, lysi...ne, tyrosine, phenylalanine, and glycerol) are in agreement with the previously determined NMR-based sets of serum biomarkers in Brazilian and/or Chinese patient samples. The same established metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD.
Кључне речи:
bipolar disorder / metabolomics / biomarkers / NMR / chemometrics / serum metabolitesИзвор:
Metabolites, 2023, 13, 5, 607-Издавач:
- MDPI AG
Финансирање / пројекти:
- Organisation for the Prohibition of Chemical Weapons (OPCW) (Project Account No: L/ICA/ICB-217652/18)
- Organisation for the Prohibition of Chemical Weapons (OPCW) (Project Account No: L/ICA/ICB-108/21)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200051 (Институт за општу и физичку хемију, Београд) (RS-MESTD-inst-2020-200051)
DOI: 10.3390/metabo13050607
ISSN: 2218-1989
PubMed: 37233648
WoS: 000996559200001
Scopus: 2-s2.0-85160306072
Институција/група
IHTMTY - JOUR AU - Simić, Katarina AU - Miladinović, Zoran AU - Todorović, Nina AU - Trifunović, Snežana AU - Avramović, Nataša AU - Gavrilović, Aleksandra AU - Jovanović, Silvana AU - Gođevac, Dejan AU - Vujisić, Ljubodrag AU - Tešević, Vele AU - Tasic, Ljubica AU - Mandić, Boris PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6682 AB - Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden. The complexity of this disease, including diverse genetic, environmental, and biochemical factors, and diagnoses based on the subjective recognition of symptoms without any clinical test of biomarker identification create significant difficulties in understanding and diagnosing BD. A 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD (33) and healthy controls (39) was explored, providing the identification of 22 metabolites for this disease. A biomarker set including threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose was established for the first time in BD serum samples by an NMR-based metabolomics study. Six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in agreement with the previously determined NMR-based sets of serum biomarkers in Brazilian and/or Chinese patient samples. The same established metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD. PB - MDPI AG T2 - Metabolites T1 - Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients VL - 13 IS - 5 SP - 607 DO - 10.3390/metabo13050607 ER -
@article{ author = "Simić, Katarina and Miladinović, Zoran and Todorović, Nina and Trifunović, Snežana and Avramović, Nataša and Gavrilović, Aleksandra and Jovanović, Silvana and Gođevac, Dejan and Vujisić, Ljubodrag and Tešević, Vele and Tasic, Ljubica and Mandić, Boris", year = "2023", abstract = "Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden. The complexity of this disease, including diverse genetic, environmental, and biochemical factors, and diagnoses based on the subjective recognition of symptoms without any clinical test of biomarker identification create significant difficulties in understanding and diagnosing BD. A 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD (33) and healthy controls (39) was explored, providing the identification of 22 metabolites for this disease. A biomarker set including threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose was established for the first time in BD serum samples by an NMR-based metabolomics study. Six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in agreement with the previously determined NMR-based sets of serum biomarkers in Brazilian and/or Chinese patient samples. The same established metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD.", publisher = "MDPI AG", journal = "Metabolites", title = "Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients", volume = "13", number = "5", pages = "607", doi = "10.3390/metabo13050607" }
Simić, K., Miladinović, Z., Todorović, N., Trifunović, S., Avramović, N., Gavrilović, A., Jovanović, S., Gođevac, D., Vujisić, L., Tešević, V., Tasic, L.,& Mandić, B.. (2023). Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients. in Metabolites MDPI AG., 13(5), 607. https://doi.org/10.3390/metabo13050607
Simić K, Miladinović Z, Todorović N, Trifunović S, Avramović N, Gavrilović A, Jovanović S, Gođevac D, Vujisić L, Tešević V, Tasic L, Mandić B. Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients. in Metabolites. 2023;13(5):607. doi:10.3390/metabo13050607 .
Simić, Katarina, Miladinović, Zoran, Todorović, Nina, Trifunović, Snežana, Avramović, Nataša, Gavrilović, Aleksandra, Jovanović, Silvana, Gođevac, Dejan, Vujisić, Ljubodrag, Tešević, Vele, Tasic, Ljubica, Mandić, Boris, "Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients" in Metabolites, 13, no. 5 (2023):607, https://doi.org/10.3390/metabo13050607 . .