Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina
Synthesis, characterization and antioxidative activity of aminolysis products of Hantzsch dihydropyridines
Apstrakt
Supstituisani estri 1,4-dihidropiridina (1,4-DHP) nastaju u reakciji etil-acetoacetata i odgovarajućih supstituisanih aldehida u prisustvu amonijaka. Nastali estri sa primarnim aminima formiraju amide. Serija amida nastalih od navednih jedinjenja je sintetisana sa namerom da se ispitaju njihove karakteristike i antioksidativna aktivnost. U ovde prikazanom istraživanju za aminolizu upotrebljen je 2-aminotiazol. Antioksidativna aktivnost je ispitivana DPPH (2,2-difenil-1-pikrilhidrazil-radikal) i ABTS (2,2'-azino-bis(3-etilbenzotiazolin-6-sulfonska kiselina)) metodama, a pored toga određene su tačke topljenje, snimljeni IR spektri i izvršena je elementalna analiza.
The substituted esters of 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of ethyl acetoacetate and corresponding substituted aldehydes in the presence of ammonia. Amides form from esters of substituted 1,4-DHP by aminolysis employing primary amines. A series of amides of the mentioned compounds was synthesized with the aim to analyze their chemical properties and antioxidative activity. The amine used in the present research was 2-aminothiazole. The antioxidative activity was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) methods; melting points and IR were measured and elemental analysis was performed.
Ključne reči:
esters / synthesis / antioxidative activityIzvor:
Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia, 2022, 140-140Izdavač:
- Beograd, Srbija : Srpsko hemijsko društvo
Finansiranje / projekti:
- Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-MESTD-Basic Research (BR or ON)-172013)
Institucija/grupa
IHTMTY - CONF AU - Nikolić, Jasmina AU - Božić, Katarina AU - Kuburović, Nataša AU - Drmanić, Saša PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6517 AB - Supstituisani estri 1,4-dihidropiridina (1,4-DHP) nastaju u reakciji etil-acetoacetata i odgovarajućih supstituisanih aldehida u prisustvu amonijaka. Nastali estri sa primarnim aminima formiraju amide. Serija amida nastalih od navednih jedinjenja je sintetisana sa namerom da se ispitaju njihove karakteristike i antioksidativna aktivnost. U ovde prikazanom istraživanju za aminolizu upotrebljen je 2-aminotiazol. Antioksidativna aktivnost je ispitivana DPPH (2,2-difenil-1-pikrilhidrazil-radikal) i ABTS (2,2'-azino-bis(3-etilbenzotiazolin-6-sulfonska kiselina)) metodama, a pored toga određene su tačke topljenje, snimljeni IR spektri i izvršena je elementalna analiza. AB - The substituted esters of 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of ethyl acetoacetate and corresponding substituted aldehydes in the presence of ammonia. Amides form from esters of substituted 1,4-DHP by aminolysis employing primary amines. A series of amides of the mentioned compounds was synthesized with the aim to analyze their chemical properties and antioxidative activity. The amine used in the present research was 2-aminothiazole. The antioxidative activity was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) methods; melting points and IR were measured and elemental analysis was performed. PB - Beograd, Srbija : Srpsko hemijsko društvo C3 - Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia T1 - Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina T1 - Synthesis, characterization and antioxidative activity of aminolysis products of Hantzsch dihydropyridines SP - 140 EP - 140 UR - https://hdl.handle.net/21.15107/rcub_cer_6517 ER -
@conference{ author = "Nikolić, Jasmina and Božić, Katarina and Kuburović, Nataša and Drmanić, Saša", year = "2022", abstract = "Supstituisani estri 1,4-dihidropiridina (1,4-DHP) nastaju u reakciji etil-acetoacetata i odgovarajućih supstituisanih aldehida u prisustvu amonijaka. Nastali estri sa primarnim aminima formiraju amide. Serija amida nastalih od navednih jedinjenja je sintetisana sa namerom da se ispitaju njihove karakteristike i antioksidativna aktivnost. U ovde prikazanom istraživanju za aminolizu upotrebljen je 2-aminotiazol. Antioksidativna aktivnost je ispitivana DPPH (2,2-difenil-1-pikrilhidrazil-radikal) i ABTS (2,2'-azino-bis(3-etilbenzotiazolin-6-sulfonska kiselina)) metodama, a pored toga određene su tačke topljenje, snimljeni IR spektri i izvršena je elementalna analiza., The substituted esters of 1,4-dihydropyirdines (1,4-DHP) are formed in the reaction of ethyl acetoacetate and corresponding substituted aldehydes in the presence of ammonia. Amides form from esters of substituted 1,4-DHP by aminolysis employing primary amines. A series of amides of the mentioned compounds was synthesized with the aim to analyze their chemical properties and antioxidative activity. The amine used in the present research was 2-aminothiazole. The antioxidative activity was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) methods; melting points and IR were measured and elemental analysis was performed.", publisher = "Beograd, Srbija : Srpsko hemijsko društvo", journal = "Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia", title = "Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina, Synthesis, characterization and antioxidative activity of aminolysis products of Hantzsch dihydropyridines", pages = "140-140", url = "https://hdl.handle.net/21.15107/rcub_cer_6517" }
Nikolić, J., Božić, K., Kuburović, N.,& Drmanić, S.. (2022). Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina. in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia Beograd, Srbija : Srpsko hemijsko društvo., 140-140. https://hdl.handle.net/21.15107/rcub_cer_6517
Nikolić J, Božić K, Kuburović N, Drmanić S. Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina. in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia. 2022;:140-140. https://hdl.handle.net/21.15107/rcub_cer_6517 .
Nikolić, Jasmina, Božić, Katarina, Kuburović, Nataša, Drmanić, Saša, "Sinteza, karakterizacija i antioksidativna aktivnost proizvoda aminolize Hančovih dihidropiridina" in Kratki izvodi radova, knjiga radova - 58. Savetovanje Srpskog hemijskog društva, 9. i 10. jun, Beograd, Srbija / Book of Abstracts, Proceedings - 58th Meeting of the Serbian Chemical Society, June 9-10, Belgrade, Serbia (2022):140-140, https://hdl.handle.net/21.15107/rcub_cer_6517 .