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Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system
dc.creator | Milić, Dragana | |
dc.creator | Kop, Tatjana | |
dc.creator | Csanadi, J. | |
dc.creator | Juranić, Zorica | |
dc.creator | Žižak, Željko | |
dc.creator | Gašić, Miroslav J. | |
dc.creator | Šolaja, Bogdan | |
dc.date.accessioned | 2019-01-30T17:22:03Z | |
dc.date.available | 2019-01-30T17:22:03Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0039-128X | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/618 | |
dc.description.abstract | A simple approach to a stable steroidal estrone derived A,B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac2O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the antiproliferative activity of the spiro-product against three cancer cell lines, are also presented. | en |
dc.publisher | Elsevier Science Inc, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142049/RS// | |
dc.rights | restrictedAccess | |
dc.source | Steroids | |
dc.subject | A,B-spiro | en |
dc.subject | Anticancer activity | en |
dc.subject | Rearrangement | en |
dc.subject | Steroidal epoxide | en |
dc.subject | TMSOTf | en |
dc.title | Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Коп, Татјана; Јураниц, З.; Гасиц, М.Ј.; Зизак, З.; Цсанади, Ј.; Милиц, Д.; Солаја, Б.; | |
dc.citation.volume | 74 | |
dc.citation.issue | 12 | |
dc.citation.spage | 890 | |
dc.citation.epage | 895 | |
dc.citation.other | 74(12): 890-895 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 19538979 | |
dc.identifier.doi | 10.1016/j.steroids.2009.06.002 | |
dc.identifier.scopus | 2-s2.0-70049110807 | |
dc.identifier.wos | 000270759500003 | |
dc.type.version | publishedVersion |