dc.creator | Pergal, Marija | |
dc.creator | Dojčinović, Biljana | |
dc.creator | Nikodinović-Runić, Jasmina | |
dc.creator | Dražić, Goran | |
dc.creator | Zabukovec Logar, Nataša | |
dc.creator | Ostojić, Sanja | |
dc.creator | Antić, Bratislav | |
dc.date.accessioned | 2023-01-23T00:07:43Z | |
dc.date.available | 2023-01-23T00:07:43Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0022-2461 | |
dc.identifier.issn | 1573-4803 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/5586 | |
dc.description.abstract | In situ polymerization was used to produce novel AgFeO2@PEG/polyurethane network nanocomposites (NP-PUs) with 30–60 wt% of soft poly(dimethylsiloxane) segments in polyurethane (PU), containing 1 wt% of PEG-coated AgFeO2 nanoparticles, AgFeO2@PEG. Physicochemical properties and in vitro biological activity of the NP-PUs were systematically evaluated in terms of AgFeO2@PEG (NP) addition and soft segment content. High-angle annular dark-field transmission electron microscopy showed that the nanoparticles were generally uniformly distributed in the PU matrix. Increased soft segment content caused significantly increased intensity of the broad, amorphous X-ray diffraction peaks of crystalline AgFeO2, probably because the chemical composition of PU affected the distribution of nanoparticles. The Young modulus, hardness, and plasticity of the NP-PUs were higher than for pure PU and increased with decreasing soft segment content. Decreased soft segment content induced higher microphase separation, increased hydrophilicity and swelling ability, but decreased cross-linking density. Additionally, NP-PUs had higher glass transition temperatures, improved thermal stability, and enhanced nanomechanical performance over pure PU. The NP-PUs demonstrated good selective inhibition of Candida albicans and Candida parapsilosis (30–55%) and no pronounced cytotoxicity to MRC5 human lung fibroblasts. Among the investigated AgFeO2@PEG/PUs, the best antifungal activity was shown by composites with 30 and 40 wt% soft segments. Consequently, the novel AgFeO2@PEG/polyurethane network nanocomposites could be further optimized to be used as biocompatible surfaces that also prevent formation of fungal biofilms. | |
dc.publisher | Springer | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | |
dc.relation | Slovenian Research Agency (P2-0393) | |
dc.relation | Slovenian Research Agency (P1-0021) | |
dc.rights | restrictedAccess | |
dc.source | Journal of Materials Science | en |
dc.subject | polymerization | |
dc.subject | nanocomposites | |
dc.subject | antifungal activity | |
dc.subject | AgFeO2@PEG/polyurethane | |
dc.title | Synthesis, physicochemical, and antimicrobial characteristics of novel poly(urethane-siloxane) network/silver ferrite nanocomposites | en |
dc.type | article | en |
dc.rights.license | ARR | |
dc.rights.holder | The Authors | |
dc.citation.volume | 57 | |
dc.citation.issue | 16 | |
dc.citation.spage | 7827 | |
dc.citation.epage | 7848 | |
dc.citation.rank | M22~ | |
dc.identifier.doi | 10.1007/s10853-022-07178-9 | |
dc.identifier.scopus | 2-s2.0-85128298290 | |
dc.identifier.wos | 00078404370001 | |
dc.type.version | publishedVersion | |