Приказ основних података о документу
Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements
dc.creator | Isaković, Aleksandra | |
dc.creator | Janković, Teodora | |
dc.creator | Harhaji, Ljubica | |
dc.creator | Kostić Rajačić, Slađana | |
dc.creator | Nikolić, Zoran | |
dc.creator | Vajs, Vlatka | |
dc.creator | Trajković, Vladimir | |
dc.date.accessioned | 2019-01-30T17:19:04Z | |
dc.date.available | 2019-01-30T17:19:04Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/478 | |
dc.description.abstract | The present study identifies xanthones gentiakochianin and gentiacaulein as the active principles responsible for the in vitro antiglioma action of ether and methanolic extracts of the plant Gentiana kochiana. Gentiakochianin and gentiacaulein induced cell cycle arrest in G2/M and G0/G1 phases, respectively, in both C6 rat glioma and U251 human glioma cell lines. The more efficient antiproliferative action of gentiakochianin was associated with its ability to induce microtubule stabilization in a cell-free assay. Both the xanthones reduced mitochondrial membrane potential and increased the production of reactive oxygen species in glioma cells, but only the effects of gentiakochianin were pronounced enough to cause caspase activation and subsequent apoptotic cell death. The assessment of structure-activity relationship in a series of structurally related xanthones from G. kochiana and Gentianella austriaca revealed dihydroxylation at positions 7, 8 of the xanthonic nucleus as the key structural feature responsible for the ability of gentiakochianin to induce microtubule-associated G2/M cell block and apoptotic cell death in glioma cells. | en |
dc.publisher | Oxford : Pergamon-Elsevier Science Ltd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145073/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142053/RS// | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic and Medicinal Chemistry | |
dc.subject | Apoptosis | en |
dc.subject | Cell cycle | en |
dc.subject | Glioma | en |
dc.subject | Oxidative stress | en |
dc.subject | Xanthone | en |
dc.title | Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Хархаји, Л.; Костић Рајачић, Слађана; Вајс, В.; Исаковиц, A.; Јанковиц, Т.; Николиц, З.; Трајковиц, В.; | |
dc.citation.volume | 16 | |
dc.citation.issue | 10 | |
dc.citation.spage | 5683 | |
dc.citation.epage | 5694 | |
dc.citation.other | 16(10): 5683-5694 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 18406151 | |
dc.identifier.doi | 10.1016/j.bmc.2008.03.069 | |
dc.identifier.scopus | 2-s2.0-43949101696 | |
dc.identifier.wos | 000256052400032 | |
dc.type.version | publishedVersion |