Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives
Аутори
Mrđan, GoranaVaštag, Đenđi
Apostolov, Suzana
Rašeta, Milena
Verbić, Tatjana
Marković, Olivera
Matijević, Borko
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Carbohydrazones and their thio analogs represent compounds obtained by condensation of carbohydrazide and thiocarbohydrazide with carbonyl compounds. Due to their structure, relatively simple synthesis, and high reactivity, mentioned derivatives have a wide range of applications in all fields. In this study, ionization constants of four newly synthesized mono(thio)carbohydrazones were determined by applying the potentiometric method. Also, the influence of specific
and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption spectra was investigated and quantified using the linear solvation energy relationships method and Catalan’s model. Finally, by applying the DPPH assay, the antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone derivatives proved to be significantly more active when compared to carbohydrazones.
Кључне речи:
carbohydrazones / biological activity / DPPH / ionization contants / LSER / thiocarbohydrazonИзвор:
Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021, 2021, 40-40Напомена:
- XIV international scientific conference contemporary materials 2021 / XIV Међународни научни скуп савремени материјали 2021, Banja Luka, 9-10.9.2021
Институција/група
IHTMTY - CONF AU - Mrđan, Gorana AU - Vaštag, Đenđi AU - Apostolov, Suzana AU - Rašeta, Milena AU - Verbić, Tatjana AU - Marković, Olivera AU - Matijević, Borko PY - 2021 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/4760 AB - Carbohydrazones and their thio analogs represent compounds obtained by condensation of carbohydrazide and thiocarbohydrazide with carbonyl compounds. Due to their structure, relatively simple synthesis, and high reactivity, mentioned derivatives have a wide range of applications in all fields. In this study, ionization constants of four newly synthesized mono(thio)carbohydrazones were determined by applying the potentiometric method. Also, the influence of specific and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption spectra was investigated and quantified using the linear solvation energy relationships method and Catalan’s model. Finally, by applying the DPPH assay, the antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone derivatives proved to be significantly more active when compared to carbohydrazones. C3 - Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021 T1 - Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives SP - 40 EP - 40 UR - https://hdl.handle.net/21.15107/rcub_cer_4760 ER -
@conference{ author = "Mrđan, Gorana and Vaštag, Đenđi and Apostolov, Suzana and Rašeta, Milena and Verbić, Tatjana and Marković, Olivera and Matijević, Borko", year = "2021", abstract = "Carbohydrazones and their thio analogs represent compounds obtained by condensation of carbohydrazide and thiocarbohydrazide with carbonyl compounds. Due to their structure, relatively simple synthesis, and high reactivity, mentioned derivatives have a wide range of applications in all fields. In this study, ionization constants of four newly synthesized mono(thio)carbohydrazones were determined by applying the potentiometric method. Also, the influence of specific and nonspecific intermolecular interactions on maxima shifting in UV-Vis absorption spectra was investigated and quantified using the linear solvation energy relationships method and Catalan’s model. Finally, by applying the DPPH assay, the antioxidant potential of the newly synthesized compounds was determined, and thiocarbohydrazone derivatives proved to be significantly more active when compared to carbohydrazones.", journal = "Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021", title = "Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives", pages = "40-40", url = "https://hdl.handle.net/21.15107/rcub_cer_4760" }
Mrđan, G., Vaštag, Đ., Apostolov, S., Rašeta, M., Verbić, T., Marković, O.,& Matijević, B.. (2021). Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives. in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021, 40-40. https://hdl.handle.net/21.15107/rcub_cer_4760
Mrđan G, Vaštag Đ, Apostolov S, Rašeta M, Verbić T, Marković O, Matijević B. Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives. in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021. 2021;:40-40. https://hdl.handle.net/21.15107/rcub_cer_4760 .
Mrđan, Gorana, Vaštag, Đenđi, Apostolov, Suzana, Rašeta, Milena, Verbić, Tatjana, Marković, Olivera, Matijević, Borko, "Investigation of physicochemical properties and potential biological activity of 2-pyridine-(thio)carbohydrazone derivatives" in Programme and the book of abstracts, 14th International Scientific Conference Contemporary Materials 2021 (2021):40-40, https://hdl.handle.net/21.15107/rcub_cer_4760 .