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Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials
dc.creator | Opsenica, Igor | |
dc.creator | Opsenica, Dejan | |
dc.creator | Smith, K. S. | |
dc.creator | Milhous, Wilbur K. | |
dc.creator | Šolaja, Bogdan | |
dc.date.accessioned | 2019-01-30T17:18:55Z | |
dc.date.available | 2019-01-30T17:18:55Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0022-2623 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/471 | |
dc.description.abstract | Of 17 prepared 1,2,4,5-tetraoxacyclohexanes stable to reductive and acidic conditions, 3 of them were more active than artemisinin against CQ and MFQ resistant strain TM91C235 and all compounds were more active in vitro against W2 than against D6 strain. In vivo, amines 10 and 11a cured all mice at higher doses with MCD ≤ 37.5 (mg/kg)/day. Triol 13 was exceptionally active against melanoma (LOX IMVI) and ovarian cancer (IGROV1), both with LC 50 = 60 nM. | en |
dc.publisher | American Chemical Society (ACS) | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Medicinal Chemistry | |
dc.title | Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Опсеница, И.; Шолаја, Б.A.; Опсеница, Дејан; Милхоус, W.К.; Смитх, К.С.; | |
dc.citation.volume | 51 | |
dc.citation.issue | 7 | |
dc.citation.spage | 2261 | |
dc.citation.epage | 2266 | |
dc.citation.other | 51(7): 2261-2266 | |
dc.citation.rank | aM21 | |
dc.identifier.pmid | 18330976 | |
dc.identifier.doi | 10.1021/jm701417a | |
dc.identifier.scopus | 2-s2.0-41849117634 | |
dc.identifier.wos | 000254709100031 | |
dc.type.version | publishedVersion |