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Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms
dc.creator | Tsoukatou, M. | |
dc.creator | Maréchal, J.P. | |
dc.creator | Hellio, C. | |
dc.creator | Novaković, Irena | |
dc.creator | Tufegdžić, Srđan | |
dc.creator | Sladić, Dušan | |
dc.creator | Gašić, Miroslav J. | |
dc.creator | Clare, A.S. | |
dc.creator | Vagias, C. | |
dc.creator | Roussis, V. | |
dc.date.accessioned | 2019-01-30T17:16:32Z | |
dc.date.available | 2019-01-30T17:16:32Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/359 | |
dc.description.abstract | The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3′-(p-chlorophenyl) avarone (3), 3′,4′-ethylenedithioavarone (4), 4′-isopropylthioavarone (5), 4′-tert-butylthioavarone (6), 4′-propylthioavarone (7), 4′-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 μg/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica). | en |
dc.publisher | MDPI | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Molecules | |
dc.subject | Antifouling activity | en |
dc.subject | Antimicrobial activity | en |
dc.subject | Avarol | en |
dc.subject | Avarone | en |
dc.subject | Settlement inhibition | en |
dc.title | Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Роуссис, В.; Вагиас, Ц.; Цларе, A.С.; Гашић, М.Ј.; Сладић, Д.; Хеллио, Ц.; Марéцхал, Ј.П.; Тсоукатоу, М.; Новаковић, Ирена; Туфегджић, Срђан; | |
dc.citation.volume | 12 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1022 | |
dc.citation.epage | 1034 | |
dc.citation.other | 12(5): 1022-1034 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 17873837 | |
dc.identifier.doi | 10.3390/12051022 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs//bitstream/id/9022/357.pdf | |
dc.identifier.scopus | 2-s2.0-34249870148 | |
dc.identifier.wos | 000247200900009 | |
dc.type.version | publishedVersion |