Приказ основних података о документу
Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA
dc.creator | Krstić, Gordana | |
dc.creator | Jadranin, Milka | |
dc.creator | Stanković, Miroslava | |
dc.creator | Aljančić, Ivana | |
dc.creator | Vujisić, Ljubodrag V. | |
dc.creator | Mandić, Boris | |
dc.creator | Tešević, Vele | |
dc.date.accessioned | 2020-05-06T07:27:56Z | |
dc.date.available | 2020-05-06T07:27:56Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | http://cherry.chem.bg.ac.rs/handle/123456789/3143 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/3514 | |
dc.description.abstract | Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3). | en |
dc.publisher | SAGE Journals | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Natural Product Communications | |
dc.subject | CBMN assay | |
dc.subject | Human lymphocytes | |
dc.subject | Jatrophanes | |
dc.subject | MN | |
dc.subject | Protective effect | |
dc.subject | SAR studies | |
dc.title | Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Крстић, Гордана; Јадранин, Милка; Станковић, Мирослава; Aљанчић, Ивана; Вујисић, Љубодраг В.; Мандић, Борис; Тешевић, Веле; | |
dc.citation.volume | 14 | |
dc.citation.issue | 5 | |
dc.citation.rank | M23~ | |
dc.identifier.doi | 10.1177/1934578X19848168 | |
dc.identifier.fulltext | https://cer.ihtm.bg.ac.rs/bitstream/id/16429/Jatrophane_Diterpenoids_With_pub_2019.pdf | |
dc.identifier.scopus | 2-s2.0-85066403028 | |
dc.identifier.wos | 000470131700031 | |
dc.type.version | publishedVersion |