dc.creator | Terzić-Jovanović, Nataša | |
dc.creator | Opsenica, Dejan | |
dc.creator | Milić, Dragana | |
dc.creator | Tinant, Bernard | |
dc.creator | Smith, K. S. | |
dc.creator | Milhous, Wilbur K. | |
dc.creator | Šolaja, Bogdan | |
dc.date.accessioned | 2019-01-30T17:16:19Z | |
dc.date.available | 2019-01-30T17:16:19Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0022-2623 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/350 | |
dc.description.abstract | The synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively. | en |
dc.publisher | American Chemical Society (ACS) | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Medicinal Chemistry | |
dc.title | Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Тинант, Б.; Милић, Д.; Милхоус, W.К.; Шолаја, Б.A.; Опсеница, Дејан; Терзић Јовановић, Наташа; Смитх, К.С.; | |
dc.citation.volume | 50 | |
dc.citation.issue | 21 | |
dc.citation.spage | 5118 | |
dc.citation.epage | 5127 | |
dc.citation.other | 50(21): 5118-5127 | |
dc.citation.rank | aM21 | |
dc.identifier.pmid | 17887664 | |
dc.identifier.doi | 10.1021/jm070684m | |
dc.identifier.scopus | 2-s2.0-35348910826 | |
dc.identifier.wos | 000250110700009 | |
dc.type.version | publishedVersion | |