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dc.creatorTerzić Jovanović, Nataša
dc.creatorOpsenica, Dejan
dc.creatorMilić, Dragana
dc.creatorTinant, B.
dc.creatorSmith, K. S.
dc.creatorMilhous, W. K.
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:16:19Z
dc.date.available2019-01-30T17:16:19Z
dc.date.issued2007
dc.identifier.issn0022-2623
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/350
dc.description.abstractThe synthesis of deoxycholic acid (DCA)- and cholic acid (CA)-derived mixed tetraoxanes revealed that N-(2-dimethylamino)ethyl derivatives are potent antimalarials in vitro and in vivo. The tetraoxanes presented in this paper are dual inhibitors: besides curing mice in vivo without observed toxic effects, they kill cancer cell lines at very low concentrations. For example, DCA and CA derivatives 16 and 25 cured 3/5 (160 mg/kg/day) and 2/5 (40 mg/kg/day, MTD >960 mg/kg), respectively, and they were extremely active against melanoma LOX IMVI cancer, LC50 = 22 nM and 69 nM, respectively.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Medicinal Chemistry
dc.titleDeoxycholic acid-derived tetraoxane antimalarials and antiproliferativesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТинант, Б.; Милић, Д.; Милхоус, W.К.; Шолаја, Б.A.; Опсеница, Дејан; Терзић Јовановић, Наташа; Смитх, К.С.;
dc.citation.volume50
dc.citation.issue21
dc.citation.spage5118
dc.citation.epage5127
dc.citation.other50(21): 5118-5127
dc.citation.rankaM21
dc.identifier.pmid17887664
dc.identifier.doi10.1021/jm070684m
dc.identifier.rcubConv_4095
dc.identifier.scopus2-s2.0-35348910826
dc.identifier.wos000250110700009
dc.type.versionpublishedVersion


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