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dc.creatorMarković, Olivera
dc.creatorPešić, Miloš P.
dc.creatorAvdeef, Alex
dc.creatorVerbić, Tatjana
dc.date.accessioned2020-02-12T16:00:56Z
dc.date.available2020-02-12T16:00:56Z
dc.date.issued2019
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/3404
dc.description.abstractThe aim of this study was to examine solubility-pH behavior of desipramine structural analogues: imipramine and amitriptyline hydrochlorides. Appearance of aggregates (trimer, around pH 4 in imipramine case), which lead to slow sedimentation, and oil forms make solubility determination extremely challenging. Oils which are more soluble than crystalline forms are formed in alkaline solutions (above pH 7.8 in imipramine case). Sometimes in such cases, pH adjustment in that pH region can be unpredictable. Furthermore, oil sticks to electrode making pH measurement difficult, especially in amitryptiline case. Concentration was measured using HPLC with UV/Vis detection. Different techniques were used for solid phase characterization. Solid phase characterization is particularly important in complicated systems like this.sr
dc.language.isoensr
dc.publisherInternational Association of Physical Chemistssr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//sr
dc.rightsopenAccesssr
dc.source8th World Conference on Physico-Chemical Methods in Drug Discovery, Split, Croatia, September 9-11, 2019 - Book of Abstractssr
dc.subjectsolubilitysr
dc.subjectpH-dependent solubilitysr
dc.subjectimipraminesr
dc.subjectamitriptylinesr
dc.subjectpH-Ramp Shake-Flask methodsr
dc.titlepH-Dependent solubility profiles of imipramine and amitriptyline hydrochloridessr
dc.typeconferenceObjectsr
dc.rights.licenseBYsr
dcterms.abstractМарковић, Оливера; Пешић, Милош П.; Вербић, Татјана Ж.; Aвдееф, Aлеx;
dc.citation.spage51
dc.citation.epage51
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/16053/bitstream_16053.pdf
dc.type.versionpublishedVersionsr


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